Results 71 to 80 of about 52,858 (287)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Regional Guidance-Based Multiscale Joint Filtering Model for SAR Images

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Synthetic aperture radar (SAR) imaging systems are characterized by their all-weather and day-and-night capabilities, enabling the acquisition of high-resolution ground imagery.
Chuang Sun, Fengcheng Guo, Zhaoling Hu, Lianpeng Zhang, Wensong Liu, Tingting Huang   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Unassisted Quantitative Evaluation Of Despeckling Filters

, 2017
SAR (Synthetic Aperture Radar) imaging plays a central role in Remote Sensing due to, among other important features, its ability to provide high-resolution, day-and-night and almost weather-independent images.
Frery, Alejandro C., Gomez, Luis, Ospina, Raydonal   +2 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Polarimetric SAR Speckle Reduction by Hybrid Iterative Filtering

IEEE Access, 2020
Speckle filtering in synthetic aperture radar polarimetry (PolSAR) is essential for the extraction of significant information. In this study, the authors introduced a hybrid iterative filtering scheme.
Mohamed Yahia, Tarig Ali, Md. Maruf Mortula, Riadh Abdelfattah, Samy El Mahdy   +4 more
doaj   +1 more source

Polarization Imperfections of Light in Interferometry [PDF]

, 2009
Disertační práce pojednává o polarizačních nedokonalostech optických komponentů, které jsou využívány ke kontrole a k transformaci polarizačního stavu světla.
Kučera, Petr
core  

Guided patch-wise nonlocal SAR despeckling

, 2018
We propose a new method for SAR image despeckling which leverages information drawn from co-registered optical imagery. Filtering is performed by plain patch-wise nonlocal means, operating exclusively on SAR data.
Cozzolino, Davide, Poggi, Giovanni, Scarpa, Giuseppe, Verdoliva, Luisa, Vitale, Sergio   +4 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source