Results 161 to 170 of about 30,394 (309)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Adam Smith and Moral Knowledge

open access: yes
This paper examines the contribution of The Theory of Moral Sentiments to the study of how we acquire moral knowledge. In Smith, this is associated with the moral judgment of an impartial spectator, a hypothetical ideal conjured in the imagination of an ...
Konow, James
core   +1 more source

Symmetry-Selective Ultrafast Charge Transfer via Cyano End Groups at the PDIF-CN<sub>2</sub>-Au(111) Interface. [PDF]

open access: yesNano Lett
Kladnik G   +6 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

open access: yesMolecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver   +2 more
wiley   +1 more source

American Literature, Lynching, and the Spectator in the Crowd Spectacular Violence

open access: yes
This book examines spectatorship in texts by Theodore Dreiser, Miriam Michelson, Irvin S. Cobb, and Paul Laurence Dunbar. As a figure who is simultaneously within and outside the crowd, the spectator is in a unique position to express the fractures ...
Lelekis, Debbie.
core  

De hertogen van Bourgondië in de Nederlanden /

open access: yes, 1875
Overdr. uit: "De Nederlandsche Spectator", 1875Recensie van : Paul Fredericq, Essai sur le rôle politique et social des Ducs de Bourgogne dans les Pays ...
Frederiks, J. G.(Johannes Godefridus),1828-1896(viaf)20671081
core  

Une image peut en cacher une autre : réflexions autour d’une exposition

open access: yesPerspective, 2009
Dario Gamboni   +2 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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