Results 61 to 70 of about 610 (146)
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia +20 more
wiley +2 more sources
Remote Sensing in Ecology and Conservation, EarlyView.In this study, we developed AnuraSearch, an open‐source classifier for 11 Ukrainian amphibian species, by repurposing the avian BirdNET algorithm via transfer learning to process over 18,000 h of autonomous acoustic recordings. Although the model demonstrated high precision and successfully reconstructed detailed seasonal and diel vocal activity ...
Vasylyna Strus +5 more
wiley +1 more source
Small, EarlyView.A three‐residue peptide bioconjugated onto a carbon nanotube quantum defect turns the near‐infrared emission of quantum defects into a reporter of integrins on intact extracellular vesicles, directly in human plasma. The sensor reveals that healthy fibroblast vesicles carry as much RGD‐binding integrin as cancer‐derived ones, an adhesion‐associated ...
In‐Jun Hwang +9 more
wiley +1 more source
PEG400 regulates Falcipain 2 activity through an allosteric mechanism
The FEBS Journal, EarlyView.Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath +2 more
wiley +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Unmarked Emotional States and the Affective Anchoring of Continuity
Sociological Forum, EarlyView.ABSTRACT Narratives around emotions often foreground remarkable episodes that interrupt situations, producing a “rollercoaster” image of emotional life that leaves its stability underdescribed. To analyze the emotional dimension of social continuity, this article theorizes unmarked emotional states (UES): culturally default, interactionally unobtrusive
Lorenzo Sabetta
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li +19 more
wiley +1 more source
Sequence‐encoded dynamics diversify allostery within a conserved protein scaffold
Protein Science, Volume 35, Issue 11, November 2026.Abstract Proteins evolve allosteric mechanisms through sequence variation while preserving a conserved structural fold. How these substitutions reshape the protein's conformational landscape to drive functional diversification remains poorly understood.
Sanuja Mohanaraj +4 more
wiley +1 more source
Soft Skins With Reversible Thickness Morphing: Materials, Mechanisms, and Applications
Advanced Materials, Volume 38, Issue 55, 1 October 2026.Evolution of electronic skin (e‐skin) technologies toward adaptive, multifunctional soft skins. Phase I highlights early rigid and discrete sensory interfaces. Phase II shows the transition toward flexible, stretchable, and large‐area e‐skin. Phase III captures the emergence of computational e‐skin.
Oliver Ozioko +2 more
wiley +1 more source