Results 61 to 70 of about 25,686,348 (370)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Knowledge Transfer Between Artificial Intelligence Systems

Frontiers in Neurorobotics, 2018
We consider the fundamental question: how a legacy “student” Artificial Intelligent (AI) system could learn from a legacy “teacher” AI system or a human expert without re-training and, most importantly, without requiring significant computational ...
Ivan Y. Tyukin, Ivan Y. Tyukin, Alexander N. Gorban, Alexander N. Gorban, Konstantin I. Sofeykov, Konstantin I. Sofeykov, Ilya Romanenko   +6 more
doaj   +1 more source

Glutarimides: Biological activity, general synthetic methods and physicochemical properties [PDF]

Hemijska Industrija, 2015
Glutarimides, 2,6-dioxopiperidines are compounds that rarely occur in natural sources, but so far isolated ones exert widespread pharmacological activities, which makes them valuable as potential pharmacotherapeutics.
Popović-Đorđević Jelena B., Vitnik Vesna D., Vitnik Željko J., Ivanović Milovan D.   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability

eLife
Autophagy-related gene 6 (ATG6) plays a crucial role in plant immunity. Nonexpressor of pathogenesis-related genes 1 (NPR1) acts as a signaling hub of plant immunity. However, the relationship between ATG6 and NPR1 is unclear.
Baihong Zhang, Shuqin Huang, Shuyu Guo, Yixuan Meng, Yuzhen Tian, Yue Zhou, Hang Chen, Xue Li, Jun Zhou, Wenli Chen   +9 more
doaj   +1 more source

Spectral ergodicity and normal modes in ensembles of sparse matrices

, 2000
We investigate the properties of sparse matrix ensembles with particular regard for the spectral ergodicity hypothesis, which claims the identity of ensemble and spectral averages of spectral correlators.
A.D. Jackson, Andersen, Anderson, Berbenni-Bitsch, Bohigas, Brody, C. Mejia-Monasterio, Flores, French, French, French, Fyodorov, Fyodorov, Fyodorov, Fyodorov, Guhr, Guhr, Guhr, Janik, Kaplan, Khorunzhy, Lee, M. Saltzer, McKane, Mirlin, Mon, Mott, Osborn, Osborn, Pluhar, Shklovskii, T. Rupp, T. Wilke, Thouless, Thouless, Thouless   +35 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Spectral analysis of multiple time series [PDF]

, 1972
Application of spectral analysis for mathematically determining relationship of random vibrations in structures and concurrent events in electric circuits, physiology, economics, and seismograms is discussed.
Dubman, M. R.
core   +1 more source

Spectral Analysis for Matrix Hamiltonian Operators

, 2010
In this work, we study the spectral properties of matrix Hamiltonians generated by linearizing the nonlinear Schr\"odinger equation about soliton solutions.
Agmon S, Asad M Simpson G, Berestycki H, Buslaev V S, Cazenave T, Coddington E A, Demanet L, Eastham M, Gideon Simpson, Hislop P, Jeremy L Marzuola, Marzuola J, Perelman G, Reed M, Rodnianski I Schlag W Soffer A, Shampine L, Simpson G Zwiers I, Stein E, Sulem C, Tao T, Tataru D, Taylor M   +21 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source