Results 91 to 100 of about 1,145,296 (299)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effect of longitudinal-angular oscillations of the harvester-thresher separator on smooth motion of the reaper

Advanced Engineering Research, 2017
Introduction. The effect of the low-frequency oscillations of the reaper on crop losses of the domestic combine harvesters is considered. In the study, various speeds of the machine, various mass-geometric and elastic-dissipative characteristics of the ...
Leonid M. Groshev, Svetlana A Partko, Andrey N. Sirotenko   +2 more
doaj   +1 more source

Properties of the phi meson at high temperatures and densities

, 2008
We calculate the spectral density of the phi meson in a hot bath of nucleons and pions using a general formalism relating self-energy to the forward scattering amplitude (FSA).
A. T. Martell, C. Gale, G. Vujanovic, J. I. Kapusta, J. Ruppert, V. L. Eletsky, W.-M. Yao   +6 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

μ Robust Stable Extrapolation of a Stationary Random Process with Interval Limited Variance

RUDN Journal of Engineering Research
A method for synthesizing μ robust stable linear minimax extrapolator of a stationary random process under conditions of interval uncertainty of the parameters of the measured signal is presented.
Igor G. Sidorov
doaj   +1 more source

Constraints on the Primordial Magnetic Field from $\sigma_8$

, 2008
A primordial magnetic field (PMF) can affect the evolution of density field fluctuations in the early universe.In this paper we constrain the PMF amplitude $B_\lambda$ and power spectral index $n_\mathrm{B}$ by comparing calculated density field ...
D. G. Yamazaki, Dai G. Yamazaki, Grant J. Mathews, Kiyotomo Ichiki, P. J. E. Peebles, S. Chandrasekhar, S. Dodelson, T. Padmanabhan, Toshitaka Kajino   +8 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Explosive Episodes and Time-Varying Volatility: A New MARMA–GARCH Model Applied to Cryptocurrencies

Econometrics
Financial assets often exhibit explosive price surges followed by abrupt collapses, alongside persistent volatility clustering. Motivated by these features, we introduce a mixed causal–noncausal invertible–noninvertible autoregressive moving average ...
Alain Hecq, Daniel Velasquez-Gaviria
doaj   +1 more source