Results 111 to 120 of about 741,207 (289)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Parallel Quadrature Spatial Modulation for Massive MIMO Systems With ICI Avoidance

IEEE Access, 2019
Despite its efficiency in conventional multiple-input multiple-output (MIMO) wireless systems, quadrature spatial modulation (QSM) becomes less efficient in massive MIMO systems since it does not adapt to the number of antennas but always uses one or two
Guosheng Huang, Chuanping Li, Sonia Aissa, Minghua Xia   +3 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Enhancing the Coexistence of LTE and Wi-Fi in Unlicensed Spectrum Through Convolutional Neural Networks

IEEE Access, 2019
Over the last years, the ever-growing wireless traffic has pushed the mobile community to investigate solutions that can assist in more efficient management of the wireless spectrum.
Vasilis Maglogiannis, Adnan Shahid, Dries Naudts, Eli De Poorter, Ingrid Moerman   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Performance Analysis of Cooperative Quadrature Spatial Modulation System With Hybrid Decode-Amplify-Forward Relaying Protocol

IEEE Access
This paper introduces the cooperative quadrature spatial modulation (CQSM) system with hybrid decode-amplify-forward (HDAF) relaying protocol. Compered with the traditional CQSM system which only uses amplify-and-forward (AF) protocol and decode-and ...
Xiangyan Bu, Ke Pang
doaj   +1 more source

Evaluating spatial dependency of the spectral efficiency in trans-palpebral illumination for widefield fundus photography. [PDF]

Biomed Opt Express, 2023
Rahimi M, Rossi A, Son T, Toslak D, Le D, Abtahi M, Heiferman MJ, Chan RVP, Yao X.   +8 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Efficient Precoding and Power Allocation Techniques for Maximizing Spectral Efficiency in Beamspace MIMO-NOMA Systems. [PDF]

Sensors (Basel), 2023
Liu Y, Si L, Wang Y, Zhang B, Xu W.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source