Results 31 to 40 of about 653,662 (247)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Information capacity of direct detection optical transmission systems

open access: yes, 2017
We show that the spectral efficiency of a direct detection transmission system is at most 1 bit/s/Hz less than the spectral efficiency of a system employing coherent detection with the same modulation format.
Mecozzi, Antonio, Shtaif, Mark
core   +1 more source

On the energy efficiency-spectral efficiency trade-off in the uplink of CoMP system [PDF]

open access: yes, 2012
In this paper, we derive a generic closed-form approximation (CFA) of the energy efficiency-spectral efficiency (EE-SE) trade-off for the uplink of coordinated multi-point (CoMP) system and demonstrate its accuracy for both idealistic and realistic power
Héliot, Fabien   +2 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

Ergodic Spectral Efficiency in MIMO Cellular Networks [PDF]

open access: yesIEEE Transactions on Wireless Communications, 2017
35 pages, 12 ...
Geordie George   +3 more
openaire   +3 more sources

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

Efficient eigen-updating for spectral graph clustering [PDF]

open access: yesNeurocomputing, 2014
Correction of several ...
Dhanjal, Charanpal   +2 more
openaire   +8 more sources

Fundamental Limits of Low-Density Spreading NOMA with Fading

open access: yes, 2018
Spectral efficiency of low-density spreading non-orthogonal multiple access channels in the presence of fading is derived for linear detection with independent decoding as well as optimum decoding.
Di Benedetto, Maria-Gabriella   +3 more
core   +1 more source

Spectral Efficiency and Energy Efficiency of OFDM Systems: Impact of Power Amplifiers and Countermeasures [PDF]

open access: yes, 2013
In wireless communication systems, the nonlinear effect and inefficiency of power amplifier (PA) have posed practical challenges for system designs to achieve high spectral efficiency (SE) and energy efficiency (EE).
Ho, Chin Keong   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy