Results 251 to 260 of about 92,516 (310)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Characterization of RGB-Polarization Sensor-Based Cameras. [PDF]

J Imaging
Karge A, Klammer M, Eberhardt B, Schilling A.   +3 more
europepmc   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Machine learning-driven optimization of monolithic gold plasmonic sensors: Achieving ultrahigh sensitivity with interpretable linear models. [PDF]

PLoS One
Akter S, Abdullah H.
europepmc   +1 more source

Adaptive spectral element methods

, 1999
Barosan, I., Vosse, van de, F.N., Meijer, H.E.H.   +2 more
openaire   +1 more source

Generative tissue modeling for customized biomechanical analysis: a data-driven synthesis framework of simulation-ready 3D shapes. [PDF]

Front Bioeng Biotechnol
Ma J, Wang Z, Wu Z, Li J, Lv Z, Cui T, Zhou B, Chen Y, Huang Y, Tang J.   +9 more
europepmc   +1 more source

Generalized Eigenvalue Problem in Subspace-Based Excited-State Methods for Quantum Computers. [PDF]

J Chem Theory Comput
Kwao PF, Poyyapakkam Sundar S, Gupt B, Asthana A.   +3 more
europepmc   +1 more source

A 33 GHz Conformal Phased-Array Radar with Linearly Constrained Minimum Variance Digital Beamforming, Circular- Polarization Filtering, and Neural-Network Micro-Doppler Classification for Counter-UAS Applications. [PDF]

Sensors (Basel)
Baginski M.
europepmc   +1 more source

High-Accuracy and Efficient Classification of Uranium Slag by Origin and Category via LIBS Integrated with Hybrid Machine Learning. [PDF]

Sensors (Basel)
Zhang M, Li H, Deng L, Hua R, Zhang X, Wu D, Wang X, Liu X, Liu Z, Liu X.   +9 more
europepmc   +1 more source

Fast automated adjoints for spectral PDE solvers. [PDF]

Proc Natl Acad Sci U S A
Skene CS, Burns KJ.
europepmc   +1 more source