Results 81 to 90 of about 7,136,334 (313)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A new AdS4/CFT3 dual with extended SUSY and a spectral flow [PDF]

, 2014
A bstractWe construct a new AdS4 background in Type IIB supergravity by means of a non-Abelian T-duality transformation on the Type IIA dual of ABJM. The analysis of probe and particle-like branes suggests a dual CFT in which each of the gauge groups is ...
Y. Lozano, Niall T. Macpherson
semanticscholar   +1 more source

Spectral Flow and Feigin-Fuks Parameter Space of N=4 Superconformal Algebras

, 1996
The parameter space of the Feigin-Fuks representations of the N=4 SU(2)$_k$ superconformal algebras is studied from the viewpoint of the specral flow. The $\eta$ phase of the spectral flow is nicely incorporated through twisted fermions and the spectral ...
Kato M., Satoshi Matsuda
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

On the spectral flow for paths of essentially hyperbolic bounded operators on Banach spaces

, 2010
We give a definition of the spectral flow for paths of bounded essentially hyperbolic operators on a Banach space. The spectral flow induces a group homomorphism on the fundamental group of every connected component of the space of essentially hyperbolic
Daniele, Garrisi
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Spectral flow, crossing forms and homoclinics of Hamiltonian systems [PDF]

, 2014
We prove a spectral flow formula for one‐parameter families of Hamiltonian systems under homoclinic boundary conditions, which relates the spectral flow to the relative Maslov index of a pair of curves of Lagrangians induced by the stable and unstable ...
Nils Waterstraat
semanticscholar   +1 more source

Spectrally informed learning of fluid flows

Chaos: An Interdisciplinary Journal of Nonlinear Science
Accurate and efficient fluid flow models are essential for applications relating to many physical phenomena, including geophysical, aerodynamic, and biological systems. While these flows may exhibit rich and multiscale dynamics, in many cases, underlying low-rank structures exist, which describe the bulk of the motion.
Benjamin D. Shaffer, Jeremy R. Vorenberg, M. Ani Hsieh   +2 more
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source