Results 261 to 270 of about 232,364 (309)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Brain adaptations in challenging walking task of people with stroke: an experimental study. [PDF]

J Neuroeng Rehabil
Zhao J, Zhuang X, Wang H, Xu H, Zhang Q, Zhang L.   +5 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Operator-level quantum acceleration of non-logconcave sampling. [PDF]

Proc Natl Acad Sci U S A
Leng J, Ding Z, Chen Z, Lin L.
europepmc   +1 more source

A spectral component approach leveraging identity-by-descent graphs to address recent population structure in genomic analysis. [PDF]

Genome Res
Shemirani R, Belbin GM, Cullina S, Caggiano C, Gignoux CR, Zaitlen N, Kenny EE.   +6 more
europepmc   +1 more source

Segmentation and Multimodal Characterization of Metal Particles in the Human Hippocampus Using Discrete Segmentation Algorithms and Correlation Spectral Analysis. [PDF]

Molecules
Pánik J, Ždímalová M, Kosnáč D, Kopáni M, Dulanská S, Kretsul N, Trnka M.   +6 more
europepmc   +1 more source

Quantum Algorithm for Identifying Hidden Graphs: Spectral Theory and Numerical Evidence

Pawel Wocjan
openalex   +1 more source

A new paradigm for stratified cognitive assessment: fusing serum Raman spectroscopy and ensemble learning. [PDF]

Alzheimers Res Ther
Mo Y, Mao C, Jiang J, Fang S, Huang L, Ke Z, Hu Z, Yang D, Xie P, Xiong R, Xu Y.   +10 more
europepmc   +1 more source

The structure-preserving spectral graph neural network for dual kinase inhibitors and synergy scoring in gastric cancer. [PDF]

NPJ Digit Med
Zhang Y, Yuan C, Wang L, Chen Y, Xing Y, Sun Y.   +5 more
europepmc   +1 more source