Results 111 to 120 of about 834,727 (299)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Confronting brane inflation with Planck and pre-Planck data

, 2013
In this paper, we compare brane inflation models with the Planck data and the pre-Planck data (which combines WMAP, ACT, SPT, BAO and H0 data). The Planck data prefer a spectral index less than unity at more than 5\sigma confidence level, and a running ...
Huang, Qing-Guo, Ma, Yin-Zhe, Zhang, Xin
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Influence of Soil Background Noise on Accuracy of Soil Moisture Content Inversion in Alfalfa Fields Based on UAV Multispectral Data

Soil Systems
Soil moisture plays a critical role in the global water cycle, the exchange of matter and energy within ecosystems, and the movement of water in plants.
Jinxi Chen, Yuanbo Jiang, Wenjing Yu, Guangping Qi, Yanxia Kang, Minhua Yin, Yanlin Ma, Yayu Wang, Jiapeng Zhu, Yanbiao Wang, Boda Li   +10 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Monitoring the Spatiotemporal Dynamics of Invasive Pedicularis kansuensis in Bayinbuluke Alpine Wetlands: A Novel Spectral Index Framework Using PlanetScope Time Series (2021–2025)

Plants
The expansion of the invasive species Pedicularis kansuensis threatens the ecological integrity of alpine wetlands, particularly in the Bayinbuluke, northwestern China. However, operational monitoring remains challenging.
Enzhao Zhu, Alim Samat, Wenbo Li, Kaiyue Luo   +3 more
doaj   +1 more source

Scale dependence of the primordial spectrum from combining the three-year WMAP, Galaxy Clustering, Supernovae, and Lyman-alpha forests

, 2006
We probe the scale dependence of the primordial spectrum in the light of the three-year WMAP (WMAP3) alone and WMAP3 in combination with the other cosmological observations such as galaxy clustering and Type Ia Supernova (SNIa).
, , , , , , , Bo Feng, Bond J R, Bridges M Lasenby A N Hobson M P, Burles S, Chen C-Y, Cline J M, Cole S Sanchez A G Wilkins S, Contaldi C R, Croft R A C, Di Pietro E, Dore O, Easther R, Feng B, Finelli F, Freedman W L, Gelma A, Guy J Astier P Nobili S Regnault N Pain R, Hinshaw G, Hodges H M, Huang Q G, Huffenberger K M, Jarosik N, Jha S, Jun-Qing Xia, Jun’ichi Yokoyama, Lewis A, Lewis A, Linde A D, Maltoni M, Matsumiya M, Page L, Sato K, Seljak U, Seljak U, Spergel D N, Tegmark M, Viel M, Wang X, Wang X F   +45 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Relating Estrada index with spectral radius

Journal of the Serbian Chemical Society, 2007
The Estrada index EE is a recently proposed molecular structure-descriptor, used in the modeling of certain features of the 3D structure of organic molecules, in particular of the degree of folding of proteins and other long-chain biopolymers. The Estrada index is computed from the spectrum of the molecular graph.
Ivan Gutman, Slavko Radenkovic, Boris Furtula, Toufik Mansour, Matthias Schork   +4 more
openaire   +4 more sources