Results 121 to 130 of about 834,727 (299)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Automated Global Method to Detect Rapid and Future Urban Areas

Land
As many areas of the world continue to grow, it is important to detect areas that are urbanizing at paces above the norm and predict future urban areas, so that optimal city planning can occur.
Heather S. Sussman, Sarah J. Becker
doaj   +1 more source

The Spectral Shift Function and the Witten Index [PDF]

, 2016
We survey the notion of the spectral shift function of a pair of self-adjoint operators and recent progress on its connection with the Witten index. We also describe a proof of Krein's Trace Theorem that does not use complex analysis [53] and develop its extension to general $ $-finite von Neumann algebras $\mathcal{M}$ of type II and unbounded ...
Carey, Alan L, Gesztesy, Fritz, Levitina, Galina, Sukochev, F   +3 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identifying the Signature of the Solar UV Radiation Spectrum

Atmosphere
The broadband spectrum of solar radiation is commonly characterized by indices such as the average photon energy (APE) and the blue fraction (BF). This work explores the effectiveness of the two indices in a narrower spectral band, namely the ultraviolet
Andrea-Florina Codrean, Octavian Madalin Bunoiu, Marius Paulescu   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Adjusting Spectral Indices for Spectral Response Function Differences of Very High Spatial Resolution Sensors Simulated from Field Spectra

Sensors, 2015
The use of data from multiple sensors is often required to ensure data coverage and continuity, but differences in the spectral characteristics of sensors result in spectral index values being different. This study investigates spectral response function
Sharon L. Cundill, Harald M. A. van der Werff, Mark van der Meijde   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Enhancing the Performance of Unmanned Aerial Vehicle-Based Estimation of Rape Chlorophyll Content by Reducing the Impact of Crop Coverage

Drones
Estimating leaf chlorophyll content (LCC) in a timely manner and accurately is of great significance for the precision management of rape. The spectral index derived from UAV images has been adopted as a non-destructive and efficient way to map LCC ...
Yaxiao Niu, Longfei Xu, Yanni Zhang, Lizhang Xu, Qingzhen Zhu, Aichen Wang, Shenjin Huang, Liyuan Zhang   +7 more
doaj   +1 more source