Results 111 to 120 of about 369,559 (294)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Multiple-field inflation and the CMB

, 2003
In this paper, we investigate some consequences of multiple-field inflation for the cosmic microwave background radiation (CMB). We derive expressions for the amplitudes, the spectral indices and the derivatives of the indices of the CMB power spectrum ...
, , Bardeen J M, Bartjan van Tent, Bartolo N, Bartolo N, Boyanovsky D, Bucher M, Bucher M, Bunn E F, Finelli F, Garcia-Bellido J, Gordon C, Groot Nibbelink S, Guth A H, Henriques A B, Hui L, Hwang J-C, Hwang J-C, Hwang J-C, Kiefer C, Kinney W H Kolb E W Melchiorri A Riotto A, Kodama H, Langlois D, Leach S M Liddle A R, Lesgourgues J, Liddle A R, Lidsey J E, Linde A D, Malik K A, Malik K A, Martin J, Martin J, Martin J, Polarski D, Polarski D, Sasaki M, Song Y-S, Starobinsky A A, Stewart J M, Tanaka T, Tanaka T Bassett B A, Tsujikawa S, Van Tent B J W, Van Tent B J W Groot Nibbelink S, Wands D, Wands D   +46 more
core   +2 more sources

The Compound Spectral Indices of Human Stress

Applied Mathematics, 2018
Temporally fine-grained and objective measures of mental states or their surrogate states are desperately needed in clinical psychiatry. Stress, both acute and especially chronic stress, is an important mental and physiological state observed in many mental disorders.
Petr Kloucek, Armin Von Gunten
openaire   +2 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Development of Spectral Disease Indices for ‘Flavescence Dorée’ Grapevine Disease Identification

Sensors, 2017
Spectral measurements are employed in many precision agriculture applications, due to their ability to monitor the vegetation’s health state. Spectral vegetation indices are one of the main techniques currently used in remote sensing activities, since ...
Hania AL-Saddik, Jean-Claude Simon, Frederic Cointault   +2 more
doaj   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Estimation of Nitrogen Concentration in Winter Wheat Leaves Based on a Novel Spectral Index and Machine Learning Model

Plants
Assessing crop nitrogen status is crucial for optimizing fertilization strategies and promoting sustainable production. Although hyperspectral data offer significant advantages for monitoring subtle physiological changes in crops, accurately determining ...
Shihao Cui, Zhijun Li, Zijun Tang, Wei Zhang, Tao Sun, Yue Wu, Wanli Yang, Guofu Chen, Youzhen Xiang, Fucang Zhang   +9 more
doaj   +1 more source

R^2-corrections to Chaotic Inflation

, 2003
Scalar density cosmological perturbations, spectral indices and reheating in a chaotic inflationary universe model, in which a higher derivative term is added, are investigated.
Linde A. D., Ramón Herrera, Sergio del Campo, Starobinsky A. A., Víctor H. Cárdenas   +4 more
core   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source