Results 61 to 70 of about 369,559 (294)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Improvement of Leaf Chlorophyll Content Estimation Using Spectral Indices From Nonpolarized Reflectance Factor in the Laboratory and Field

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020
Optical properties of light reflected from leaves can be described by both intensity and polarization, however, most studies focused on the intensity in the estimation of plant leaf biochemical parameters.
Yuefeng Li, Zhongqiu Sun, Shan Lu, Kenji Omasa   +3 more
doaj   +1 more source

A Complete Reference of the Analytical Synchrotron External Shock Models of Gamma-Ray Bursts

, 2013
Gamma-ray bursts are most luminous explosions in the universe. Their ejecta are believed to move towards Earth with a relativistic speed. The interaction between this "relativistic jet" and a circum burst medium drives a pair of (forward and reverse ...
Gao, He, Lei, Wei-Hua, Wu, Xue-Feng, Zhang, Bing, Zou, Yuan-Chuan   +4 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Identifying drought events in sugarcane using drought indices derived from Modis sensor [PDF]

Pesquisa Agropecuária Brasileira, 2017
: The objective of this work was to evaluate the potential of several spectral indices, used on moderate resolution imaging spectroradiometer (Modis) images, in identifying drought events in sugarcane.
Michelle Cristina Araujo Picoli, Daniel Garbellini Duft, Pedro Gerber Machado   +2 more
doaj   +2 more sources

The Spitzer Infrared Spectrograph Survey of T Tauri Stars in Taurus [PDF]

, 2011
We present 161 Spitzer Infrared Spectrograph (IRS) spectra of T Tauri stars and young brown dwarfs in the Taurus star-forming region. All of the targets were selected based on their infrared excess and are therefore surrounded by protoplanetary disks ...
Adame, L., Calvet, N., D'Alessio, P., Espaillat, C., Fischer, W. J., Forrest, W. J., Furlan, E., Green, Joel D., Kim, K. H., Luhman, K. L., Manoj, P., McClure, M. K., Sargent, B. A., Watson, D. M.   +13 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Climate-Based Regionalization and Inclusion of Spectral Indices for Enhancing Transboundary Land-Use/Cover Classification Using Deep Learning and Machine Learning

Remote Sensing, 2021
Accurate land use and cover data are essential for effective land-use planning, hydrological modeling, and policy development. Since the Okavango Delta is a transboundary Ramsar site, managing natural resources within the Okavango Basin is undoubtedly a ...
Blessing Kavhu, Zama Eric Mashimbye, Linda Luvuno   +2 more
doaj   +1 more source

Early Results from VLT-SPHERE: Long-Slit Spectroscopy of 2MASS 0122-2439B, a Young Companion Near the Deuterium Burning Limit [PDF]

, 2015
We present 0.95-1.80 $\mu$m spectroscopy of the $\sim$12-27 $M_{\rm Jup}$ companion orbiting the faint ($R$$\sim$13.6), young ($\sim$120 Myr) M-dwarf 2MASS J01225093--2439505 ("2M0122--2439 B") at 1.5 arcsecond separation (50 AU).
Aller, Kimberly M., Baraffe, Isabelle, Bowler, Brendan P., Chabrier, Gilles, Hinkley, Sasha, Kraus, Stefan, Liu, Michael C., Matthews, Elisabeth, Mawet, Dimitri, Vigan, Arthur, Wahhaj, Zahed   +10 more
core   +4 more sources