Results 91 to 100 of about 7,700,165 (256)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Autoregressive models of singular spectral matrices

open access: yesAutomatica, 2012
This paper deals with autoregressive (AR) models of singular spectra, whose corresponding transfer function matrices can be expressed in a stable AR matrix fraction description [Formula: see text] with [Formula: see text] a tall constant matrix of full column rank and with the determinantal zeros of [Formula: see text] all stable, i.e. in [Formula: see
Anderson, Brian   +3 more
openaire   +5 more sources

Spectral calibration of exponential Lévy Models [2] [PDF]

open access: yes
The calibration of financial models has become rather important topic in recent years mainly because of the need to price increasingly complex options in a consistent way.
Denis Belomestny, Markus Reiß
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Modeling Land-Cover Types Using Multiple Endmember Spectral Mixture Analysis in a Desert City [PDF]

open access: yes
Spectral mixture analysis is probably the most commonly used approach among sub-pixel analysis techniques. This method models pixel spectra as a linear combination of spectral signatures from two or more ground components.
Soe W. Myint, Gregory S. Okin
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Developing in situ Non-Destructive Estimates of Crop Biomass to Address Issues of Scale in Remote Sensing

open access: yesRemote Sensing, 2015
Ground-based estimates of aboveground wet (fresh) biomass (AWB) are an important input for crop growth models. In this study, we developed empirical equations of AWB for rice, maize, cotton, and alfalfa, by combining several in situ non-spectral and ...
Michael Marshall, Prasad Thenkabail
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Detecting Confounding in Multivariate Linear Models via Spectral Analysis

open access: yesJournal of Causal Inference, 2018
We study a model where one target variable Y$Y$ is correlated with a vector X:=(X1,…,Xd)$\textbf{X}:=(X_1,\dots,X_d)$ of predictor variables being potential causes of Y$Y$.
Janzing Dominik, Schölkopf Bernhard
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

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