Results 51 to 60 of about 254,314 (265)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Variety Identification of Single Rice Seed Using Hyperspectral Imaging Combined with Convolutional Neural Network

Applied Sciences, 2018
The feasibility of using hyperspectral imaging with convolutional neural network (CNN) to identify rice seed varieties was studied. Hyperspectral images of 4 rice seed varieties at two different spectral ranges (380–1030 nm and 874–1734 nm) were acquired.
Zhengjun Qiu, Jian Chen, Yiying Zhao, Susu Zhu, Yong He, Chu Zhang   +5 more
doaj   +1 more source

Spectral embedding of regularized block models

CoRR, 2019
Spectral embedding is a popular technique for the representation of graph data. Several regularization techniques have been proposed to improve the quality of the embedding with respect to downstream tasks like clustering. In this paper, we explain on a simple block model the impact of the complete graph regularization, whereby a constant is added to ...
de Lara, Nathan, Bonald, Thomas
openaire   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Spectral nudging in a spectral regional climate model

Tellus A: Dynamic Meteorology and Oceanography, 2008
Spectral nudging, a dynamic downscaling method, has been used as a suitable approach to force a regional model to adopt prescribed large-scales over the entire domain, not just at the lateral boundaries, while developing realistic detailed regional features consistent with the large-scales.
Radu, Raluca, Déqué, Michel, Somot, Samuel   +2 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Spectral Bounds and Exit Times for a Stochastic Model of Corruption

Mathematical and Computational Applications
We study a stochastic differential model for the dynamics of institutional corruption, extending a deterministic three-variable system—corruption perception, proportion of sanctioned acts, and policy laxity—by incorporating Gaussian perturbations into ...
José Villa-Morales
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Developing models to detect maize diseases using spectral vegetation indices derived from spectral signatures

Egyptian Journal of Remote Sensing and Space Sciences
Maize, a vital global crop, faces numerous challenges, including outbreaks. This study explores the use of spectral vegetation indices for the early detection of maize diseases in individual leaves based on crop phenology at the vegetative, tasselling ...
Basani Lammy Nkuna, Johannes George Chirima, Solomon W. Newete, Adolph Nyamugama, Adriaan Johannes van der Walt   +4 more
doaj   +1 more source