Results 81 to 90 of about 254,314 (265)

Model selection for spectral parameterization.

bioRxiv : the preprint server for biology
Neurophysiological brain activity comprises rhythmic (periodic) and arrhythmic (aperiodic) signal elements, which are increasingly studied in relation to behavioral traits and clinical symptoms. Current methods for spectral parameterization of neural recordings rely on user-dependent parameter selection, which challenges the replicability and ...
Wilson, Luc E., Castanheira, Jason da Silva, Kinder, Benjamin Lévesque, Baillet, Sylvain   +3 more
openaire   +2 more sources

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Spectral Transform for the Ising Model

Annales Henri Poincaré
We prove a correspondence between Ising models in a torus and the algebro-geometric data of a Harnack curve with a certain symmetry and a point in the real part of its Prym variety, extending the correspondence between dimer models and Harnack curves and their Jacobians due to Kenyon and Okounkov.
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Enhancing beam structural damage detection using spectral moment values and spectral moment cumulative function models

Journal of Low Frequency Noise, Vibration and Active Control
Evaluation and identification of structural damage play a crucial role in ensuring the safety and reliability of structures. This study explores the application of spectral moment value analysis as a robust tool to assess and detect structural damage ...
Thanh Q Nguyen, Thuy T Nguyen, Phuoc T Nguyen   +2 more
doaj   +1 more source

Estimation of Spectral Solar Irradiance Toward Deriving Spectral Mismatch Factor Across Diverse Photovoltaic Technologies by Using Aerosol Optical Properties

Remote Sensing
This study presents a machine-learning framework for predicting spectral solar irradiance from 300 to 1100 nm using the random forest and neural network models.
Chang Ki Kim, Hyun-Goo Kim, Myeongchan Oh, Boyoung Kim, Chang-Yeol Yun   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Detecting Confounding in Multivariate Linear Models via Spectral Analysis

Journal of Causal Inference, 2018
We study a model where one target variable Y$Y$ is correlated with a vector X:=(X1,…,Xd)$\textbf{X}:=(X_1,\dots,X_d)$ of predictor variables being potential causes of Y$Y$.
Janzing Dominik, Schölkopf Bernhard
doaj   +1 more source