Results 91 to 100 of about 256,947 (266)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Fast-Acquiring High-Quality Prony Series Parameters of Asphalt Concrete through Viscoelastic Continuous Spectral Models. [PDF]

Materials (Basel), 2022
Zhang Y, Sun Y.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Detecting Confounding in Multivariate Linear Models via Spectral Analysis

Journal of Causal Inference, 2018
We study a model where one target variable Y$Y$ is correlated with a vector X:=(X1,…,Xd)$\textbf{X}:=(X_1,\dots,X_d)$ of predictor variables being potential causes of Y$Y$.
Janzing Dominik, Schölkopf Bernhard
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Enhancing beam structural damage detection using spectral moment values and spectral moment cumulative function models

Journal of Low Frequency Noise, Vibration and Active Control
Evaluation and identification of structural damage play a crucial role in ensuring the safety and reliability of structures. This study explores the application of spectral moment value analysis as a robust tool to assess and detect structural damage ...
Thanh Q Nguyen, Thuy T Nguyen, Phuoc T Nguyen   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Spectrally regularised LVMs: A spectral regularisation framework for latent variable models designed for single-channel applications

SoftwareX
Latent variable models (LVMs) are commonly used to capture the underlying dependencies, patterns, and hidden structures in observed data. Source duplication is a by-product of the data Hankelisation pre-processing step common to single-channel LVM ...
Ryan Balshaw, P. Stephan Heyns, Daniel N. Wilke, Stephan Schmidt   +3 more
doaj   +1 more source

Spectral Transform for the Ising Model

Annales Henri Poincaré
We prove a correspondence between Ising models in a torus and the algebro-geometric data of a Harnack curve with a certain symmetry and a point in the real part of its Prym variety, extending the correspondence between dimer models and Harnack curves and their Jacobians due to Kenyon and Okounkov.
openaire   +2 more sources