Results 61 to 70 of about 43,100 (215)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

QUIJOTE scientific results

Astronomy & Astrophysics
We introduce a novel approach to estimate the spectral index, βs, of polarised synchrotron emission, combining the moment expansion of Cosmic Microwave Background foregrounds and the constrained Internal Linear Combination method.
Adak D., Rubiño-Martín J. A., Génova-Santos R. T., Remazeilles M., Almeida A., Aryan K., Ashdown M., Barreiro R. B., Bose U., Cepeda-Arroita R., Casas J. M., Fernández-Torreiro M., Martínez-Gonzalez E., Poidevin F., Rebolo R., Vielva P.   +15 more
doaj   +1 more source

Synthesis, Characterization and Antimicrobial Studies of a New Mannich Base N-[Morpholino(phenyl)methyl]acetamide and Its Cobalt(II), Nickel(II) and Copper(II) Metal Complexes

E-Journal of Chemistry, 2012
A new Mannich base N-[morpholino(phenyl)methyl]acetamide (MBA), was synthesized and characterized by spectral studies. Chelates of MBA with cobalt(II), nickel(II) and copper(II) ions were prepared and characterized by elemental analyses, IR and UV ...
L. Muruganandam, K. Krishnakumar
doaj   +1 more source

Seismic Collapse Assessment of a 20-Story Steel Moment-Resisting Frame Structure

Buildings, 2014
The 2010 edition of the load standard in the United States (U.S.), ASCE 7-10, (Minimum Design Loads for Buildings and Other Structures) introduced risk-targeted spectral acceleration values for the estimation of seismic design loads. In this study, a 20-
Annika Mathiasson, Ricardo A. Medina
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Synthesis of Two Steroids Derivatives and its Relationship with some Physicochemical Parameters

E-Journal of Chemistry, 2012
Two danazol derivatives were synthesized and characterized by spectral analyses. In order to characterize the structural and physicochemical requirements of danazol derivatives, several parameters such HOMO-LUMO gap, ΔHf, RMSg, dipole moment (µ) and bond
Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, Elodia Garcia-Cervera   +2 more
doaj   +1 more source

The Role of the Hyperfine Structure for the Determination of Improved Level Energies of Ta II, Pr II and La II

Atoms, 2017
For the determination of improved energy levels of ionic spectra of elements with large values of nuclear magnetic dipole moment (and eventually large values of nuclear quadrupole moments), it is necessary to determine the center of gravity of spectral ...
Laurentius Windholz
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Energy budgeting of laboratory hydraulic fracturing in granite with different viscosity injection fluids

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
In this study, we investigated the source parameters of microseismicity detected during laboratory hydraulic fracturing (HF) of granite conducted with high- (gear oil/1000 cP) and low- (water/1 cP) viscosity injection fluids.
A. Butt, A. Hedayat, O. Moradian
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source