Results 71 to 80 of about 24,560 (299)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Estimation of Dynamic Latent Variable Models Using Simulated Nonparametric Moments [PDF]

. Given a model that can be simulated, conditional moments at a trial parameter value can be calculated with high accuracy by applying kernel smoothing methods to a long simulation.
Michael Creel, Dennis Kristensen
core  

The unity of instantaneous spectral moments and physical moments

, 2012
A modulated oscillation in two or three dimensions can be represented as the trajectory traced out in space by a particle orbiting an ellipse, the properties of which vary as a function of time. Generalizing ideas from signal analysis, the signal variability can be described in terms of kinematic quantities, the instantaneous moments, that formalize ...
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Generalized Spectral Moments of the Iterated Line Graphs Sequence. A Novel Approach to QSPR Studies

, 2019
The spectral moments of the iterated line graph sequence (ILGS) are defined and expressed in terms of structural fragments of the molecular graphs, i.e., embedding frequencies.
Ernesto Estrada (2518132)
core   +1 more source

Ground Clutter and Noise Mitigation Based on Range–Doppler Spectral Processing for Polarimetric Weather Radar

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Spectral polarization filtering in the range–Doppler domain plays an important role in weather radar clutter mitigation. However, when ground clutter and precipitation overlap, these methods tend to filter out clutter-contaminated precipitation ...
Mengyun An, Jiapeng Yin, Jiankai Huang, Xue Tan, Yongzhen Li   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Universal twinkling exponents for spectral fluctuations associated with mixed chaology [PDF]

, 2000
For systems that are neither fully integrable nor fully chaotic, bifurcations of periodic orbits give rise to semiclassically emergent singularities in the fluctuating part Nfl of the energy-level counting function. The bifurcations dominate the spectral
Keating, J. P., Schomerus, H., Berry, MV, Keating, JP, Schomerus, H, Berry, M. V.   +5 more
core  

Spectral moments of the real Ginibre ensemble

The Ramanujan Journal
AbstractThe moments of the real eigenvalues of real Ginibre matrices are investigated from the viewpoint of explicit formulas, differential and difference equations, and large N expansions. These topics are inter-related. For example, a third-order differential equation can be derived for the density of the real eigenvalues, and this can be used to ...
Byun, SS, Forrester, PJ
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source