Results 61 to 70 of about 927,050 (285)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Spectral Singularities of Sturm-Liouville Problems with Eigenvalue-Dependent Boundary Conditions

Abstract and Applied Analysis, 2009
Let L denote the operator generated in L2(R+) by Sturm-Liouville equation −y′′+q(x)y=λ2y, x∈R+=[0,∞), y′(0)/y(0)=α0+α1λ+α2λ2, where q is a complex-valued function and αi∈ℂ, i=0,1,2 with α2≠0.
Elgiz Bairamov, Nihal Yokus
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

A generalized spectral collocation method with tunable accuracy for fractional differential equations with end-point singularities

, 2017
We develop spectral collocation methods for fractional differential equations with variable order with two end-point singularities. Specifically, we derive three-term recurrence relations for both integrals and derivatives of the weighted Jacobi ...
George Em Karniadakis, Fanhai Zeng, Zeng, F., Mao, Z., Karniadakis, G. E., Zhiping Mao   +5 more
core   +1 more source

Infrared singularities in multi-leg scattering amplitudes [PDF]

, 2014
I discuss the state-of-the-art knowledge of long-distance singularities in multi-leg gauge-theory scattering amplitudes and report on an on-going calculation of the three-loop soft anomalous dimension through the renormalization of correlators of semi ...
Einan Gardi, Gardi, Einan; id_orcid
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

An efficient finite element method and error analysis for eigenvalue problem of Schrödinger equation with an inverse square potential on spherical domain

Advances in Difference Equations, 2020
We provide an effective finite element method to solve the Schrödinger eigenvalue problem with an inverse potential on a spherical domain. To overcome the difficulties caused by the singularities of coefficients, we introduce spherical coordinate ...
Yubing Sui, Donghao Zhang, Junying Cao, Jun Zhang   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Projection spectral analysis: A unified approach to PCA and ICA with incremental learning

ETRI Journal, 2018
Projection spectral analysis is investigated and refined in this paper, in order to unify principal component analysis and independent component analysis.
Hoon Kang, Hyun Su Lee
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source