Results 31 to 40 of about 1,232,276 (317)
Proteomic tools to study drug function [PDF]
, 2018 With the ever growing repertoire of drugs being developed, new unbiased methods are urgently needed that allow fast screening of protein targets and off-targets.
Leijten, Niels +4 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Liquid chromatography-tandem mass spectrometry - Application in the clinical laboratory [PDF]
, 2003 This review provides a concise survey of liquid chromatography tandem mass spectrometry (LCTMS) as an emerging technology in clinical chemistry. The combination of two mass spectrometers with an interposed collision cell characterizes LCTMS as an ...
Michael Vogeser, Vogeser, Michael
core +1 more source
Molecules, 2021 This article presents studies on iron speciation in the pottery obtained from archaeological sites. The determination of iron forms Fe(II) and Fe(III) has been provided by a very simple test that is available for routine analysis involving the technique ...
Lidia Kozak +5 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Absorption mode FTICR mass spectrometry imaging
, 2013 Fourier transform ion cyclotron resonance mass spectrometry offers the highest mass resolving power for molecular imaging experiments. This high mass resolving power ensures that closely spaced peaks at the same nominal mass are resolved for proper image
Konijnenburg, Marco +11 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2013 Digital staining for the automated annotation of mass spectrometry imaging (MSI) data has previously been achieved using state-of-the-art classifiers such as random forests or support vector machines (SVMs).
Köthe, U. +7 more
core +1 more source
Sensors, 2013 In this study, we focused on microfluidic electrochemical analysis of zinc complexes (Zn(phen)(his)Cl2, Zn(his)Cl2) and ZnS quantum dots (QDs) using printed electrodes.
Lukas Nejdl +12 more
doaj +1 more source
COMPUTER SIMULATION OF GAMMA-RAY DETECTOR BASED ON SCINTILLATION CRYSTALS AND SILICON PHOTOMULTIPLIERS [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2018 Subject of Research. The paper considers the principles of realization of the gamma-radiation detector based on a silicon photoelectron multiplier and a scintillation crystal with the use of an optical matching scheme. Method.
Bokatyi I.O. +5 more
doaj +1 more source