Results 11 to 20 of about 959 (179)

Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins. [PDF]

J Mol Recognit
ABSTRACT The B‐cell lymphoma 2 (BCL2) proteins are a class of apoptosis regulators that control the release of apoptogenic factors from mitochondria. Under normal physiological conditions, apoptosis is inhibited through the actions of anti‐apoptotic (repressor) BCL2 proteins that bind semi‐indiscriminately to the helical BH3 domains of pro‐apoptotic ...
Amarasiri HADB, Arachchige D, Vince MJK, Holub JM.   +3 more
europepmc   +2 more sources

Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA-mCherry protein. [PDF]

FEBS J
An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Žeželj L, Bele T, Panevska A, Bajc G, Kejžar J, Bahun M, Poklar Ulrih N, Levak V, Skočaj M, Popošek LL, Veranič P, Resnik N, Sepčić K.   +12 more
europepmc   +2 more sources

Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation. [PDF]

Adv Sci (Weinh)
Inspired by the prolactin secretion profile under normal physiological conditions, biomimetic prolactin‐releasing microneedles are designed. Under the control of near infrared (NIR), these responsive microneedles facilitate pulsed release of prolactin to inhibit fatty liver formation.
Yin H, Tang W, Huang D, Gan J, Zhang P, Zhao Y, Bi Y.   +6 more
europepmc   +2 more sources

Spectropolarimetry of supernovae [PDF]

Annual Review of Astronomy and Astrophysics, 2008
A new technique is introduced for testing the validity of the spherical symmetry approximation of the Baade method for determining distances to supernovae.Lines with P Cygni profiles produced by resonance scattering in an expanding atmosphere with non-circular isophotes should show a linear polarization in excess of that in the continuum.
Wang, Lifan, Wheeler, J. Craig
openaire   +3 more sources

mxCSM: A 100-slit, 6-wavelength wide-field coronal spectropolarimeter for the study of the dynamics and the magnetic fields of the solar corona

Frontiers in Astronomy and Space Sciences, 2016
remendous progress has been made in the field of observational coronal magnetometry in the first decade of the 21st century. With the successful construction of the Coronal Multichannel Magnetometer (CoMP) instrument, observations of the linear ...
Haosheng eLin
doaj   +1 more source

The Histone Chaperones SET/TAF‐1β and NPM1 Exhibit Conserved Functionality in Nucleosome Remodeling and Histone Eviction in a Cytochrome c‐Dependent Manner

Advanced Science, Volume 10, Issue 29, October 17, 2023., 2023
This study focuses on the molecular action of two histone chaperones: SET/template‐activating factor‐Iβ and nucleophosmin 1. It is shown how these chaperones have specificity for fully dismantled nucleosomes, characterized the histone eviction (removal) process, and its modulation by cytochrome c.
Pedro Buzón, Alejandro Velázquez‐Cruz, Laura Corrales‐Guerrero, Antonio Díaz‐Quintana, Irene Díaz‐Moreno, Wouter H. Roos   +5 more
wiley   +1 more source

Early Time Spectropolarimetry of the Aspherical Type II Supernova SN 2023ixf

The Astrophysical Journal Letters, 2023
We present six epochs of optical spectropolarimetry of the Type II supernova (SN) 2023ixf ranging from ∼2 to 15 days after the explosion. Polarimetry was obtained with the Kast double spectrograph on the Shane 3 m telescope at Lick Observatory ...
Sergiy S. Vasylyev, Yi Yang, Alexei V. Filippenko, Kishore C. Patra, Thomas G. Brink, Lifan Wang, Ryan Chornock, Raffaella Margutti, Elinor L. Gates, Adam J. Burgasser, Preethi R. Karpoor, Natalie LeBaron, Emma Softich, Christopher A. Theissen, Eli Wiston, WeiKang Zheng   +15 more
doaj   +1 more source

Molecular basis of the interactions between the disordered Neh4 and Neh5 domains of Nrf2 and CBP/p300 in oxidative stress response. [PDF]

Protein Sci
Abstract Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major transcription factor that functions in maintaining redox homeostasis in cells. It mediates the transcription of cytoprotective genes in response to environmental and endogenous stresses to prevent oxidative damage. Thus, Nrf2 plays a significant role in chemoprevention.
Karunatilleke NC, Brickenden A, Choy WY.
europepmc   +2 more sources

“Smart” Matrix Microneedle Patch Made of Self‐Crosslinkable and Multifunctional Polymers for Delivering Insulin On‐Demand

Advanced Science, Volume 10, Issue 30, October 26, 2023., 2023
A self‐crosslinkable and multifunctional polymer‐based matrix microneedle (mMN) patch is developed, which is capable of stabilizing highly concentrated insulin and delivering insulin on demand as demonstrated by in vitro analyses and in vivo efficacy studies.
Jackie Fule Liu, Amin GhavamiNejad, Brian Lu, Sako Mirzaie, Melisa Samarikhalaj, Adria Giacca, Xiao Yu Wu   +6 more
wiley   +1 more source

Exoplanet science with SPIRou: near-infrared precision velocimetry and spectropolarimetry

Comptes Rendus. Physique, 2023
High-precision radial-velocity measurements in the near-infrared allow one to search for exoplanet signals around the lowest-mass stars, including young ones.
Moutou, Claire, Donati, Jean-François, Debras, Florian   +2 more
doaj   +1 more source