Results 11 to 20 of about 891 (131)
Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA‐mCherry protein [PDF]
The FEBS Journal, Volume 293, Issue 4, Page 1150-1167, February 2026.An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Luka Žeželj +12 more
wiley +2 more sources
Inhibitory Potential and Binding Thermodynamics of Scyllatoxin‐Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins [PDF]
Journal of Molecular Recognition, Volume 38, Issue 2, March 2025.ABSTRACT The B‐cell lymphoma 2 (BCL2) proteins are a class of apoptosis regulators that control the release of apoptogenic factors from mitochondria. Under normal physiological conditions, apoptosis is inhibited through the actions of anti‐apoptotic (repressor) BCL2 proteins that bind semi‐indiscriminately to the helical BH3 domains of pro‐apoptotic ...
H. A. D. B. Amarasiri +3 more
wiley +2 more sources
Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation [PDF]
Advanced Science, Volume 12, Issue 36, September 25, 2025.Inspired by the prolactin secretion profile under normal physiological conditions, biomimetic prolactin‐releasing microneedles are designed. Under the control of near infrared (NIR), these responsive microneedles facilitate pulsed release of prolactin to inhibit fatty liver formation.
Hongli Yin +6 more
wiley +2 more sources
Molecular basis of the interactions between the disordered Neh4 and Neh5 domains of Nrf2 and CBP/p300 in oxidative stress response [PDF]
Protein Science, Volume 33, Issue 9, September 2024.Abstract Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major transcription factor that functions in maintaining redox homeostasis in cells. It mediates the transcription of cytoprotective genes in response to environmental and endogenous stresses to prevent oxidative damage. Thus, Nrf2 plays a significant role in chemoprevention.
Nadun C. Karunatilleke +2 more
wiley +2 more sources
Intelligent spectropolarimetry [PDF]
Light: Science & ApplicationsFakun Wang, Qi Jie Wang
doaj +2 more sources
Early Time Spectropolarimetry of the Aspherical Type II Supernova SN 2023ixf
The Astrophysical Journal Letters, 2023 We present six epochs of optical spectropolarimetry of the Type II supernova (SN) 2023ixf ranging from ∼2 to 15 days after the explosion. Polarimetry was obtained with the Kast double spectrograph on the Shane 3 m telescope at Lick Observatory ...
Sergiy S. Vasylyev +15 more
doaj +1 more source
Advanced Science, Volume 10, Issue 30, October 26, 2023., 2023 A self‐crosslinkable and multifunctional polymer‐based matrix microneedle (mMN) patch is developed, which is capable of stabilizing highly concentrated insulin and delivering insulin on demand as demonstrated by in vitro analyses and in vivo efficacy studies.
Jackie Fule Liu +6 more
wiley +1 more source
Exoplanet science with SPIRou: near-infrared precision velocimetry and spectropolarimetry
Comptes Rendus. Physique, 2023 High-precision radial-velocity measurements in the near-infrared allow one to search for exoplanet signals around the lowest-mass stars, including young ones.
Moutou, Claire +2 more
doaj +1 more source
Protein Science, Volume 32, Issue 10, October 2023., 2023 Abstract The repair of double‐strand DNA breaks (DSBs) by homologous recombination is crucial in the maintenance of genome integrity. While the key role of the Mre11‐Rad50‐Nbs1 (MRN) complex in repair is well known, hSSB1 (SOSSB and OBFC2B), one of the main components of the sensor of single‐stranded DNA (SOSS) protein complex, has also been shown to ...
Serene El‐Kamand +10 more
wiley +1 more source
The Astrophysical Journal Supplement Series, 2023 Faraday rotation measures (RMs) have been used for many studies of cosmic magnetism, and in most cases having more RMs is beneficial for those studies.
C. L. Van Eck +13 more
doaj +1 more source