Results 81 to 90 of about 7,764,522 (352)

FTD spectrum: Neuroimaging across the FTD spectrum [PDF]

, 2019
Frontotemporal dementia is a complex and heterogeneous neurodegenerative disease that encompasses many clinical syndromes, pathological diseases, and genetic mutations. Neuroimaging has played a critical role in our understanding of the underlying pathophysiology of frontotemporal dementia and provided biomarkers to aid diagnosis. Early studies defined
openaire   +2 more sources

Age at autism spectrum disorder diagnosis: A systematic review and meta-analysis from 2012 to 2019

Autism, 2020
Between 1990 and 2012, the global mean age at diagnosis of autism spectrum disorder ranged from 38 to 120 months. Measures have since been introduced to reduce the age at autism spectrum disorder diagnosis, but the current global mean age is unknown ...
Maarten van 't Hof, C. Tisseur, Ina van Berckelear-Onnes, Annemyn D Y van Nieuwenhuyzen, A. Daniels, M. Deen, H. Hoek, W. Ester   +7 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Notes on the Idea of a Species: A Look at Human/Neandertal Interbreeding [PDF]

, 2018
Unearthed within the limestone quarries that lie east of Dusseldorf in Germany, the first fossil to be recognized as an ancient hominin brought solid evidence to the table for starting to find answers to the question of where humans came ...
Corrow, Hannah
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Effect of Concomitant Immunotherapy and Stereotactic Radiotherapy, and of Location on Survival in Patients With Brain Metastases From Melanoma

Cancer Medicine
Background Melanoma is one of the most common causes of brain metastases (BM). Despite recent therapeutic advances, survival in patients with brain metastases from melanoma (MBM) is dismal.
Chiel B. Nijboer, Djura Piersma, Angelique E. J. Sijben, Besim Hoti, Matthijs van der Meulen   +4 more
doaj   +1 more source

Cost-effectiveness of different treat-to-target strategies in rheumatoid arthritis: results from the DREAM registry

BMC Rheumatology, 2019
Background Adjusting medication of patients with rheumatoid arthritis (RA) until predefined disease activity targets are met, i.e. Treat-to-Target (T2T), is the currently recommended treatment approach.
Celine J. van de Laar, Martijn A. H. Oude Voshaar, Harald E. Vonkeman   +2 more
doaj   +1 more source

“The thing is, to adapt is traditional”: Environmental Change and its Effects on Traditional Ecological Knowledge in the Eastern United States [PDF]

, 2015
In this essay, I examine the transformation of traditional ecological knowledge, particularly that concerning plant knowledge pertaining to medicine. I argue that this transformation is a result of an environmental history influenced by the presence of a
Bassett, Alecia
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Integrating Gender Identity and Sexual Orientation in Population-Based Administrative Data

International Journal of Population Data Science
Information regarding biological sex is collected for administrative and clinical purposes, and often is conflated with gender in clinical encounters as well as in population-based data studies. Sex is collected as either ‘male’ or ‘female’, adhering to
Mikayla Hunter, Nathan Nickel, The SPECTRUM Partnership   +2 more
doaj   +1 more source