Results 81 to 90 of about 3,788,707 (345)

Cost-effectiveness of different treat-to-target strategies in rheumatoid arthritis: results from the DREAM registry

BMC Rheumatology, 2019
Background Adjusting medication of patients with rheumatoid arthritis (RA) until predefined disease activity targets are met, i.e. Treat-to-Target (T2T), is the currently recommended treatment approach.
Celine J. van de Laar, Martijn A. H. Oude Voshaar, Harald E. Vonkeman   +2 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

The spectrum and the signless Laplacian spectrum of coronae

Linear Algebra and its Applications, 2012
AbstractLet G1,G2 be two simple connected graphs. Denote the corona and the edge corona of G1,G2 by G1∘G2 and G1♢G2, respectively. In this paper, we first introduce a new invariant, the M-coronal of a graph matrix M, where the matrix M is associated with a graph in a prescribed way.
Gui-Xian Tian, Shu-Yu Cui
openaire   +2 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Evaluation of Trigger Tool Methodology Related to Adverse Drug Events in Hospitalized Patients

Patient Safety, 2019
Purpose: To determine why an inpatient has had one of the following occurrences in the electronic health record due to an adverse drug event (ADE): international normalized ratio (INR) > 6, plasma blood glucose ≤ 50 mg/dL, or naloxone administration use.
Sara Kolc Brown, Jacob Peterson, Shayne Harris Schiedel, Kari Vavra Janes   +3 more
doaj   +1 more source

Vampyrum spectrum

Mammalian Species, 1982
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
L., Daniel Navarro, Wilson, Don E.
openaire   +2 more sources

Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication.

Archives of General Psychiatry, 2007
CONTEXT There is growing recognition that bipolar disorder (BPD) has a spectrum of expression that is substantially more common than the 1% BP-I prevalence traditionally found in population surveys. OBJECTIVE To estimate the prevalence, correlates, and
K. Merikangas, H. Akiskal, J. Angst, P. Greenberg, R. Hirschfeld, M. Petukhova, R. Kessler   +6 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The Effect of Concomitant Immunotherapy and Stereotactic Radiotherapy, and of Location on Survival in Patients With Brain Metastases From Melanoma

Cancer Medicine
Background Melanoma is one of the most common causes of brain metastases (BM). Despite recent therapeutic advances, survival in patients with brain metastases from melanoma (MBM) is dismal.
Chiel B. Nijboer, Djura Piersma, Angelique E. J. Sijben, Besim Hoti, Matthijs van der Meulen   +4 more
doaj   +1 more source