Results 81 to 90 of about 6,098,114 (358)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Cacao’s Relationship with Mesoamerican Society [PDF]

open access: yes, 2013
We know what we eat, but do we eat what we know? Our diet extends far beyond nutrients and food availability—we imbue food with cultural significance. The meaning and use of a particular food is subject to change over time, but the fact that it holds a ...
Christopher, Hillary
core   +1 more source

Shear Power Spectrum Reconstruction using Pseudo-Spectrum Method

open access: yes, 2010
We develop a pseudo power spectrum technique for measuring the lensing power spectrum from weak lensing surveys in both the full sky and flat sky limits.
Bacon   +43 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Cost-effectiveness of different treat-to-target strategies in rheumatoid arthritis: results from the DREAM registry

open access: yesBMC Rheumatology, 2019
Background Adjusting medication of patients with rheumatoid arthritis (RA) until predefined disease activity targets are met, i.e. Treat-to-Target (T2T), is the currently recommended treatment approach.
Celine J. van de Laar   +2 more
doaj   +1 more source

“The thing is, to adapt is traditional”: Environmental Change and its Effects on Traditional Ecological Knowledge in the Eastern United States [PDF]

open access: yes, 2015
In this essay, I examine the transformation of traditional ecological knowledge, particularly that concerning plant knowledge pertaining to medicine. I argue that this transformation is a result of an environmental history influenced by the presence of a
Bassett, Alecia
core   +1 more source

Coopetition spectrum trading in cognitive radio networks [PDF]

open access: yes, 2013
Spectrum trading is a promising method to improve spectrum usage efficiency. Several issues must be addressed, however, to enable spectrum trading that goes beyond conservative trading idle bands and achieve cooperation between primary and secondary ...
Cui, L, Znati, T
core   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Notes on the Idea of a Species: A Look at Human/Neandertal Interbreeding [PDF]

open access: yes, 2018
Unearthed within the limestone quarries that lie east of Dusseldorf in Germany, the first fossil to be recognized as an ancient hominin brought solid evidence to the table for starting to find answers to the question of where humans came ...
Corrow, Hannah
core   +1 more source

On the Rationality of the Spectrum

open access: yesJournal of Fourier Analysis and Applications, 2017
Let $ \subset \mathbb{R}$ be a compact set with measure $1$. If there exists a subset $ \subset \mathbb{R}$ such that the set of exponential functions $E_ :=\{e_ (x) = e^{2 i x}|_ : \in \}$ is an orthonormal basis for $L^2( )$, then $ $ is called a spectrum for the set $ $.
Debashish Bose, Shobha Madan
openaire   +3 more sources

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