Results 161 to 170 of about 436,980 (282)

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

open access: yesAdvanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu   +10 more
wiley   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

open access: yesAdvanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin   +9 more
wiley   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

open access: yesAdvanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao   +23 more
wiley   +1 more source

Boosting Fast‐Charging Performance of Ni‐Rich NCM9055 Cathodes with Nb2O5 Dual Functional Modification

open access: yesAdvanced Science, EarlyView.
A dual‐functional Nb2O5 modulation strategy is reported to overcome kinetic limitations in Ni‐rich cathodes. The formation of LiNbO3 phase at the grain boundary of the polycrystalline NCM9055 cathode preserves a radially aligned microstructure and establishes fast lithium‐ion pathways.
Tian Rao   +11 more
wiley   +1 more source

Electric‐Field Control of Terahertz Response via Spin‐Corner‐Layer Coupling in Altermagnetic Bilayers

open access: yesAdvanced Science, EarlyView.
A spin‐corner‐layer coupling mechanism is proposed in 2D altermagnetic bilayers. Exemplified by NiZrI6, the spin, layer, and topological corner states are simultaneously controlled by an ultralow electric field, enabling active modulation of terahertz absorption, emission, and polarization.
Jianhua Wang   +6 more
wiley   +1 more source

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