Results 111 to 120 of about 656,141 (223)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

Phase Transitions of the Multifractal Spectrum [PDF]

open access: yesarXiv, 2016
We consider the multifractal analysis of the pointwise dimension for Gibbs measures on countable Markov shifts. Our paper analyses the set of non-analytic points or phase transitions of the multifractal spectrum. By Sarig's thermodynamic formalism for countable Markov shifts and Iommi's expression of the multifractal spectrum, we apply analyticity ...
arxiv  

Mapping Hsp104 interactions using cross‐linking mass spectrometry

open access: yesFEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal   +3 more
wiley   +1 more source

Simulation of radio wave penetration method based on impulse

open access: yesGong-kuang zidonghua, 2013
In order to solve problem of less information and complex detection work existed in conventional radio wave penetration method, the paper proposed a radio wave penetration method with time-domain pulsed based on impulse.
LEI Kai-li, TAN Fei
doaj  

On the peripheral spectrum of positive elements [PDF]

open access: yesarXiv, 2017
We investigate the peripheral spectrum of irreducible positive elements of an ordered Banach algebra. In particular, we give conditions under which the peripheral spectrum contains (or coincides with) the cyclic group generated by a root of unity, and conditions under which the whole spectrum is invariant under the action of this cyclic group.
arxiv  

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

open access: yesFEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel   +13 more
wiley   +1 more source

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