Results 151 to 160 of about 37,610 (289)

Structure of the boson missing-mass spectrum

open access: yes, 1972
Previously, the authors described a possible threefold structure of the boson missing-mass spectrum of the process pi /sup -/+p to X/sup - /+p (see Progr. Theor. Phys., vol. 47, 1974, 1972). New data have since been obtained and the present note examines
Namiki, M, Ohba, I
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Reflections on Ijtihad and Moderate Islam

open access: yesAmerican Journal of Islam and Society, 2005
My remarks focus on two central themes addressed in the preceding debate: moderate Muslim and ijtihad. Although my assignment requires me to engage the five illustrious interlocutors, I have chosen to refer to salient aspects of their statements ...
Louay Safi
doaj  

Impact of Dialogical Communicative Acts in the Mathematical Argumentation of Students with Autism Spectrum Disorder. A Case Study on Inclusive Education

open access: yes, 2022
Inclusive Education aims to improve the presence, participation and learning of all students. From this perspective, this article focuses on the learning of mathematics, for which it was analyzed how dialogical communicative acts impact the argumentation of mathematics of students with Autism Spectrum Disorder (ASD) during the development of ...
openaire   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye   +11 more
wiley   +1 more source

Essential spectrum and Weyl asymptotics for discrete Laplacians

open access: yes
In this paper, we investigate spectral properties of discrete Laplacians. Our study is based on the Hardy inequality and the use of super-harmonic functions. We recover and improve lower bounds for the bottom of the spectrum and of the essential spectrum.
BONNEFONT, Michel, GOLENIA, Sylvain
core  

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

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