Results 61 to 70 of about 37,610 (289)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PT-symmetry and Integrability

open access: yesActa Polytechnica, 2007
We briefly explain some simple arguments based on pseudo Hermiticity, supersymmetry and PT-symmetry which explain the reality of the spectrum of some non-Hermitian Hamiltonians.
A. Fring
doaj  

On the Singular Spectrum of the Radiation Operator for Multiple and Extended Observation Domains

open access: yesInternational Journal of Antennas and Propagation, 2013
The problem of studying how spatial diversity impacts on the spectrum (singular values) of the radiation operator is addressed. This topic is of great importance because of its connection with the so-called number of degrees of freedom concept which in ...
Raffaele Solimene   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Specific EEG sleep pattern in the prefrontal cortex in primary insomnia. [PDF]

open access: yesPLoS ONE, 2015
OBJECTIVE:To assess the specific prefrontal activity in comparison to those in the other main cortical areas in primary insomnia patients and in good sleepers. METHODS:Fourteen primary insomnia patients and 11 good sleepers were included in the analysis.
Joy Perrier   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Phenomenology of buoyancy-driven turbulence: recent results

open access: yesNew Journal of Physics, 2017
In this paper, we describe the recent developments in the field of buoyancy-driven turbulence with a focus on energy spectrum and flux. Scaling and numerical arguments show that the stably-stratified turbulence with moderate stratification has kinetic ...
Mahendra K Verma   +2 more
doaj   +1 more source

Masterstudium auch für Fachhochschulen ein Muss!

open access: yesCHIMIA, 2006
Arguments for the introduction of master programs at the Universities of Applied Sciences (UAS) are presented. The concept of a consecutive Bologna master program for Chemistry and Life Sciences currently elaborated by members of the concerned ...
Jean-Nicolas Aebischer
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Scalar glueball spectrum

open access: yes, 2015
We discuss scenarios for scalar glueballs using arguments based on sum rules, spectral decomposition, the 1Nc approximation, the scales of the strong interaction and the topology of the flux tubes.
Vento Torres, Vicente
core   +1 more source

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