Results 91 to 100 of about 5,578,954 (386)

Eculizumab in Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder.

open access: yesNew England Journal of Medicine, 2019
BACKGROUND Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, autoimmune, inflammatory disorder that typically affects the optic nerves and spinal cord.
S. Pittock   +14 more
semanticscholar   +1 more source

Missed diagnoses and misdiagnoses of adults with autism spectrum disorder

open access: yesEuropean Archives of Psychiatry and Clinical Neuroscience, 2020
Autism spectrum disorder (ASD) is a group of life-long neurodevelopmental disorders affecting 1.5% of the general population. The present study aimed to evaluate the psychiatric history of a group of adults who received the first diagnosis of ASD in two ...
L. Fusar-Poli   +3 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Autism Spectrum Disorder - A Complex Genetic Disorder

open access: yesFolia Medica, 2015
Autism spectrum disorder is an entity that reflects a scientific consensus that several previously separated disorders are actually a single spectrum disorder with different levels of symptom severity in two core domains - deficits in social ...
Ivanov Hristo Y.   +3 more
doaj   +1 more source

Vitamin D Deficiency During Pregnancy and Autism Spectrum Disorders Development

open access: yesFrontiers in Psychiatry, 2020
Autism spectrum disorder is a neurodevelopmental disorder characterized by reduced social interactions, impaired communications, and stereotypic and repetitive behavior with different degrees of severity.
Nicola Principi, Susanna Esposito
doaj   +1 more source

Social Difficulties in Youth with Autism With and Without Anxiety and ADHD Symptoms [PDF]

open access: yes, 2018
Social difficulties inherent to autism spectrum disorder are often linked with co‐occurring symptoms of anxiety and attention deficit hyperactivity disorder (ADHD).
Carlson, Mary E.   +12 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

From the emotional integration to the cognitive construction: the developmental approach of Turtle Project in children with autism spectrum disorder [PDF]

open access: yes, 2016
Background: Children with autism spectrum disorder show a deficit in neurobiological processes. This deficit hinders the development of intentional behavior and appropriate problem-solving, leading the child to implement repetitive and stereotyped ...
Bianchi di Castelbianco, F.   +5 more
core   +1 more source

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