Results 41 to 50 of about 482,388 (265)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An Active RIS-Aided DFRC System for Improved Multi-User Communications

IEEE Open Journal of the Communications Society
The rapid evolution towards sixth-generation (6G) communications necessitates substantial enhancements in data rates, latency, and spectrum efficiency.
Ravi Patel, Aayush Singh, Keshav Singh, Shahid Mumtaz, Chih-Peng Li, Sudip Biswas   +5 more
doaj   +1 more source

Time series forecasting model of future spectrum demands for mobile broadband networks in Malaysia, Turkey, and Oman

Alexandria Engineering Journal, 2022
Mobile broadband (MBB) services are rapidly growing, causing a massive increase in mobile data traffic growth. This surge in data traffic is due to several factors (such as the massive increase of subscribers, mobile applications, etc.) which have led to
Ibraheem Shayea, Abdulraqeb Alhammadi, Ayman A. El-Saleh, Wan Haslina Hassan, Hafizal Mohamad, Mustafa Ergen   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Power Series Approach for Hybrid-Duplex UAV Communication Systems Under Rician Shadowed Fading

IEEE Access, 2019
A hybrid-duplex (HBD) UAV communication system (UCS), i.e., HBD-UCS, to improve spectrum utilization is investigated in this work. By considering the combined effect of fading and shadowing, a comprehensive outage probability analysis of the HBD-UCS ...
Tan Zheng Hui Ernest, A. S. Madhukumar, Rajendra Prasad Sirigina, Anoop Kumar Krishna   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The QoE Driven Transmission Optimization Based on Cognitive Air Interface Match for Self-Organized Wireless Body Area Network

IEEE Access, 2019
This paper studied the optimization of air interface (AI) allocation in self-organized wireless body area network (WBAN), for the quality of experience (QoE) of wireless data transmission between patients' body base station and the medical surveillance ...
Changhua Yao, Yongxing Jia, Lei Wang
doaj   +1 more source

5G Technology: Towards Dynamic Spectrum Sharing Using Cognitive Radio Networks

IEEE Access, 2020
The explosive popularity of small-cell and Internet of Everything devices has tremendously increased traffic loads. This increase has revolutionised the current network into 5G technology, which demands increased capacity, high data rate and ultra-low ...
W. S. H. M. W. Ahmad, N. A. M. Radzi, F. S. Samidi, A. Ismail, F. Abdullah, M. Z. Jamaludin, M. N. Zakaria   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source