Results 71 to 80 of about 528,139 (301)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A New Method in Pilot Reuse Factor Selection in Spectrum Efficient Massive MIMO Systems

open access: yesElektronika ir Elektrotechnika, 2019
Spectrum efficiency studies of Massive MIMO systems have continued and still have not been fully explored in the literature. Therefore, the spectrum efficiency definition of a particular user in a cell in a Massive MIMO network is expressed in this paper.
Osman Dikmen, Selman Kulac
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Joint energy efficiency and spectral efficiency optimization algorithm for UDN under the restriction of interference threshold and backhaul capacity

open access: yesTongxin xuebao, 2019
Aiming at the scenarios which consider the constraint of backhaul capacity restriction and interference threshold in ultra-dense networks (UDN),an integer linear programming (ILP) and Lagrangian dual decomposition (LDD) based joint optimization algorithm
Xuanli WU, Xu CHEN
doaj  

Multiuser Massive MIMO Systems With Time-Offset Pilots and Successive Interference Cancellation

open access: yesIEEE Access, 2019
This paper proposes time-offset pilots for a single-cell multiuser massive multiple-input multiple-output (MIMO) system and studies its performance under the minimum mean-squared error channel estimator and successive interference cancellation.
The Khai Nguyen   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Shared carrier vertical network transformation algorithm in heterogeneous wireless networks

open access: yesTongxin xuebao, 2012
In order to enhance the spectrum efficiency in heterogeneous wireless networks,the idea of dynamic spectrum allocation (DSA) used in cognitive radio was introduced into the heterogeneous wireless networks,the idea of vertical handoff for multi-mode ...
Liang ZHAO   +3 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Performance analysis of relay selection strategy with selective decode-and-forward protocol based on threshold decision

open access: yesDianxin kexue, 2016
Cooperative transmission can effectively overcome performance degradation caused by channel fading and thus improve diversity effect.In order to improve the spectral efficiency of all-time cooperative,relay selection strategy with selective decode-and ...
Jianwu ZHANG   +3 more
doaj  

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