Results 101 to 110 of about 3,100,217 (361)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Stable charge density wave phase in a 1T-TiSe$_2$ monolayer

, 2017
Charge density wave (CDW) phases are symmetry-reduced states of matter in which a periodic modulation of the electronic charge frequently leads to drastic changes of the electronic spectrum, including the emergence of energy gaps.
Hsu, Chuang-Han, Lin, Hsin, Pereira, Vitor M., Singh, Bahadur, Tsai, Wei-Feng   +4 more
core   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

The Numerical Sausage [PDF]

, 1994
The renormalization group equation describing the evolution of the metric of the non linear sigma models poses some nice mathematical problems involving functional analysis, differential geometry and numerical analysis.
Belardinelli, Lorenzo, Onofri, Enrico
core  

Hydrodynamics of Binary Fluid Mixtures - An Augmented Multiparticle Collison Dynamics Approach

, 2018
The Multiparticle Collision Dynamics technique (MPC) for hydrodynamics simulations is generalized to binary fluid mixtures and multiphase flows, by coupling the particle-based fluid dynamics to a Ginzburg-Landau free-energy functional for phase ...
Eisenstecken, Thomas, Gompper, Gerhard, Hornung, Raphael, Winkler, Roland G.   +3 more
core   +1 more source

Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing

Scientific Reports, 2017
RBM10 is an RNA splicing regulator that is frequently mutated in lung adenocarcinoma (LUAD) and has recently been proposed to be a cancer gene. How RBM10 mutations observed in LUAD affect its normal functions, however, remains largely unknown.
Jiawei Zhao, Yue Sun, Yin Huang, Fan Song, Zengshu Huang, Yufang Bao, J. Zuo, D. Saffen, Zhen Shao, Wen Liu, Yongbo Wang   +10 more
semanticscholar   +1 more source

Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia

Journal of Neurodevelopmental Disorders, 2020
Rare genetic variants contribute to the etiology of both autism spectrum disorder (ASD) and schizophrenia (SCZ). Most genetic studies limit their focus to likely gene-disrupting mutations because they are relatively easier to interpret their effects on ...
K. Ishizuka, Tomoyuki Yoshida, T. Kawabata, Ayako Imai, H. Mori, H. Kimura, T. Inada, Y. Okahisa, J. Egawa, M. Usami, I. Kushima, M. Morikawa, T. Okada, M. Ikeda, A. Branko, D. Mori, T. Someya, N. Iwata, N. Ozaki   +18 more
semanticscholar   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Variation in plant functional traits explains the substitution distribution and allocation strategy of Stipa species across natural grasslands of Ningxia, Northern China

Ecology and Evolution
Functional traits reflect plants' adaptability to their environment, and environmental gradients influence their distribution. But few studies have investigated the link between these traits and species substitution patterns or the relevant ecological ...
Jun Yang, Xiaowei Li, Junlong Yang, Shuang Yu, Hongmei Zhang, Bo Yang   +5 more
doaj   +1 more source