Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang +16 more
wiley +1 more source
Heliyon, 2023 Alzheimer's disease (AD) is associated with disruption at the level of a large-scale complex network. To explore the underlying mechanisms in the progression of AD, graph theory was used to quantitatively analyze the topological properties of structural ...
Zhiyuan Yang +4 more
doaj
On the peripheral spectrum of positive elements [PDF]
arXiv, 2017 We investigate the peripheral spectrum of irreducible positive elements of an ordered Banach algebra. In particular, we give conditions under which the peripheral spectrum contains (or coincides with) the cyclic group generated by a root of unity, and conditions under which the whole spectrum is invariant under the action of this cyclic group.
arxiv
The vacuum ultraviolet absorption spectrum of norbornadiene: Vibrational analysis of the singlet and triplet valence states of norbornadiene by configuration interaction and density functional calculations [PDF]
, 2021 Michael H. Palmer +6 more
openalex +1 more source
Heterozygous variants in AP4S1 are not associated with a neurological phenotype
Annals of Clinical and Translational Neurology, EarlyView.Abstract Biallelic loss‐of‐function variants in AP4S1 cause childhood‐onset hereditary spastic paraplegia. A recent report suggested that heterozygous AP4S1 variants lead to a syndrome of lower limb spasticity and dysregulation of sphincter function. We critically evaluate this claim against clinical observations in 28 heterozygous carriers of the same
Vicente Quiroz +9 more
wiley +1 more source
Semi-Fredholm and semi-Browder spectrums for the $α$-times integrated semigroups [PDF]
arXiv, 2018 In this paper, we describe the different spectrums of the {\alpha}-times integrated semigroups by the spectrums of their generators. Specially, essential ascent and descent, upper and lower semi-Fredholm and semi-Browder spectrums.
arxiv
Perceptive- Cognitive Functional Learning Model Based on The Self-Management of Students with Autistic Spectrum Disorder: A Comparative Analysis [PDF]
, 2019 Manuel Ojea Rúa
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective We measured clinical and quantitative MRI outcome measures in CMT1A to assess long‐term responsiveness, establish longitudinal validity and assess MRI as a bridging biomarker. Methods Twenty patients with CMT1A and 20 matched controls underwent MRI, myometry and clinical assessments up to four times over mean 4‐year follow‐up ...
Matthew R. B. Evans +8 more
wiley +1 more source
Cerebral autoregulation in patients with acute lacunar infarction: a reliable predictor of outcome
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective To further investigate the association between dynamic cerebral autoregulation (dCA) and the outcomes in patients with acute lacunar infarction. Methods Patients were prospectively and consecutively enrolled at The First Hospital of Jilin University between 2016 and 2023. dCA was monitored at 1–3 and 7–10 days after the stroke.
Xiang‐Kun Si +7 more
wiley +1 more source