Results 71 to 80 of about 23,732 (299)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Evidence-based intervention for preschool children with primary speech and language impairments: Child Talk – an exploratory mixed-methods study

Programme Grants for Applied Research, 2015
Background: The Child Talk study aimed to develop an evidence-based framework to support the decision-making of speech and language therapists (SLTs) as they design and plan interventions appropriate to the needs of individual children with primary ...
Sue E Roulstone, Julie E Marshall, Gaye G Powell, Juliet Goldbart, Yvonne E Wren, Jane Coad, Norma Daykin, Jane E Powell, Linda Lascelles, William Hollingworth, Alan Emond, Tim J Peters, Jon I Pollock, Cres Fernandes, Jenny Moultrie, Sam A Harding, Lydia Morgan, Helen F Hambly, Naomi K Parker, Rebecca A Coad   +19 more
doaj   +1 more source

Diagnosis of Autism

Pediatric Neurology Briefs, 2003
The identification and assessment process for children with autism and autistic spectrum disorder is reviewed by a developmental pediatrician, speech and language therapist, and consultant in pediatric disability at Guy’s and St Thomas’ Hospitals, and ...
J Gordon Millichap
doaj   +1 more source

Profile of users receiving Speech-Language Therapy service at a Critical Patient Unit

Revista CEFAC, 2020
Objective: to describe the profile of patients treated by Speech-Language therapists in a Critical Patient Unit. Methods: an ex post facto, observational and descriptive study was carried out.
Manuel del Campo Rivas, Pamela Estay Jorquera, Gabriela Valencia Rojas, Paula Muñoz Ramos, Karen Arce Rossel, Angélica Silva-Ríos   +5 more
doaj   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Impact of developmental language disorders on mental health and well-being across the lifespan: a qualitative study including the perspectives of UK adults with DLD and Australian speech-language therapists

BMJ Open
Objective This study aims to explore the educational, occupational and socioemotional experiences of people with developmental language disorder (DLD) across the lifespan to gain insight into risk and protective factors for mental health.Design ...
Suze Leitão, Adrienne Wilmot, Mark Boyes, Rachel Sievers, Courtenay Norbury   +4 more
doaj   +1 more source

Oral motor praxis in individuals with autism spectrum disorders in the context of modern speech and language therapy

Social Welfare: Interdisciplinary Approach, 2014
The objective of the submitted contribution is to describe the issue of oral motor praxis in individuals with autism spectrum disorders (ASD). The initial section of the contribution deals with the theoretical solutions relating to the given issue and ...
Kateřina Vitásková, Alena Říhová
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Diagnoza i postępowanie logopedyczne 
w nauczaniu języka polskiego jako obcego

Postscriptum Polonistyczne, 2020
The article describes how to use the competence of a speech therapist in teaching Polish as a foreign language (especially at the early stage of the glottodidactic process).
Maria Czempka-Wewióra, Karolina Graboń
doaj