Results 31 to 40 of about 52,333 (258)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2020 The paper presents a speech generative model that provides an efficient way of generating speech waveform from its amplitude spectral envelopes. The model is based on hybrid speech representation that includes deterministic (harmonic) and stochastic ...
M. Taha +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
EURASIP Journal on Audio, Speech, and Music ProcessingSpeech coding is a method to reduce the amount of data needs to represent speech signals by exploiting the statistical properties of the speech signal. Recently, in the speech coding process, a neural network prediction model has gained attention as the ...
Gebremichael Kibret Sheferaw +3 more
doaj +1 more source
Acta Universitatis Carolinae Philologica, 2017 The paper examines the fictional representation of anger in English. The emotion is identified by its lexical indication in the reporting clause (said angrily) accompanied by the direct speech which is assumed to verbalize the emotion.
Aleš Klégr, Pavlína Šaldová
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A parametric prosody coding approach for Mandarin speech using a hierarchical prosodic model
EURASIP Journal on Audio, Speech, and Music Processing, 2018 In this paper, a novel parametric prosody coding approach for Mandarin speech is proposed. It employs a hierarchical prosodic model (HPM) as a prosody-generating model in the encoder to analyze the speech prosody of the input utterance to obtain a ...
Chen-Yu Chiang
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
EURASIP Journal on Advances in Signal Processing, 2003 A dynamic programming-based optimization strategy for a temporal decomposition (TD) model of speech and its application to low-rate speech coding in storage and broadcasting is presented.
Bradley Alan B +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source