Results 181 to 190 of about 1,679,078 (335)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Temporal integration in human auditory cortex is predominantly yoked to absolute time. [PDF]

Nat Neurosci
Norman-Haignere SV, Keshishian M, Devinsky O, Doyle W, McKhann GM, Schevon CA, Flinker A, Mesgarani N.   +7 more
europepmc   +1 more source

Artificial Tactile Perception System for Exploring Internal and External Features of Objects via Time‐Frequency Features

Advanced Science, EarlyView.
By engaging in different active exploration behaviors, the tactile perception system can generate distinct signal modes, enabling the application of targeted decoding strategies for efficient and accurate perception of both external and internal object features.
Yuanzhi Zhou, Jingqi Zhang, Linyi Li, Muxing Huang, Ziyi Zhang, Xingmin Lu, Zilan Li, Xuchun Gui, Xinming Li   +8 more
wiley   +1 more source

Trustworthy AI-IoT for Citizen-Centric Smart Cities: The IMTPS Framework for Intelligent Multimodal Crowd Sensing. [PDF]

Sensors (Basel)
Li W, Li K, Xu Z, Wu M, Wu Y, Xiong Y, Huang S, Yin Y, Ma Y, Zhang H.   +9 more
europepmc   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Surgical placement possibilities, audiological benefit, and quality of life following Bonebridge implantation in children. [PDF]

PLoS One
Urík M, Šikolová S, Kruntorád V, Hošnová D, Šíma J.   +4 more
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Audio Deepfake Detection via a Fuzzy Dual-Path Time-Frequency Attention Network. [PDF]

Sensors (Basel)
Li J, Wang H, Xie F, Feng X, Chen J, Liu J, Wang J.   +6 more
europepmc   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Bulbar Manifestation of Myasthenia Gravis Initially Attributed to Goiter: A Case Report. [PDF]

OTO Open
El Zoert Z, Howeiss P, El Lakis M, Hazimeh Y.   +3 more
europepmc   +1 more source