Results 71 to 80 of about 219,283 (268)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Pedagogical conditions for ensuring continuity in the development of coherent speech in older preschool children and first graders

Современное дошкольное образование
Background. Modern educational approaches place significant emphasis on the continuity and consistency of learning, creating optimal conditions for children’s successful adaptation during the transition from preschool to primary education.
Olga V. Romanova
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Sensorimotor Rhythms as Neurophysiological Correlates of Speech Perception Processes in Childhood

Национальный психологический журнал
Background. The contribution of the sensorimotor neural network to speech perception has only recently been identified and described in adults. In children, the association between neurophysiological correlates of sensorimotor activity and speech ...
Vladimir A. Lipatov , Polina A. Pavlova , Anna B. Rebreikina , Olga V. Sysoeva   +3 more
doaj   +1 more source

TO THE QUESTION ABOUT THE CONSIDERATION OF THE PECULIARITIES OF SPEECH DEVELOPMENT OF BILINGUAL CHILDREN IN EDUCATIONAL PROCESS

Вестник Северо-Кавказского федерального университета, 2022
The article discusses the nature of bilingualism and the peculiarities of the speech development of bilingual children. There are represented a pedagogical conditions conducive to the effective organization of educational process in bilingual children ...
Irina Istomina
doaj  

Methodology- and speech-oriented training of the future Master students majoring in Preschool Education

Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського, 2019
The article is focused on the problem dealing with the methodology- and speech-oriented training of the future Master students majoring in Pre-school Education.
Bogush Alla
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

The Association Between Atypical Speech Development and Adolescent Self-Harm. [PDF]

J Speech Lang Hear Res, 2023
McAllister J, Skinner J, Hayhow R, Heron J, Wren Y.   +4 more
europepmc   +1 more source