Results 71 to 80 of about 498,468 (303)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Vocal and articulatory speech control deficits in individuals with post-stroke aphasia

Scientific Reports
Individuals with post-stroke aphasia exhibit deficits in regulating vocal (i.e., laryngeal) pitch control during speech vowel production; however, it is not determined whether such deficits also exist when they control their supra-laryngeal speech ...
Roozbeh Behroozmand, Zeinab Khoshhal Mollasaraei, Vahid Nejati, Ayoub Daliri, Julius Fridriksson   +4 more
doaj   +1 more source

Effects of attentional instructions on neural and behavioral correlates of vocal auditory feedback control in post-stroke aphasia

NeuroImage
Existing evidence supports the notion that feedback-based attentional instructions can modulate vocal sensorimotor control mechanisms. Here, we investigated whether such instructions can improve the neural and behavioral functions for vocal auditory ...
Yilun Zhang, Roozbeh Behroozmand
doaj   +1 more source

Frequency Modulation and Spatiotemporal Stability of the sCPG in Preterm Infants with RDS

International Journal of Pediatrics, 2012
The nonnutritive suck (NNS) is an observable and accessible motor behavior which is often used to make inference about brain development and pre-feeding skill in preterm and term infants.
Steven M. Barlow, Mimi Burch, Lalit Venkatesan, Meredith Harold, Emily Zimmerman   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Morbidity and Mortality ofVery Low Birth Weight Infant Graduates of a Level Three Neonatal Intensive Care Unit [PDF]

, 2007
Purpose: To describe the morbidity and mortality of very low birth weight (VLBW) infant graduates of a level three neonatal intensive care unit (NICU) in a medically underserved population.
Cortes, Maria
core   +1 more source

Charles West: a 19th century perspective on acquired childhood aphasia [PDF]

, 2005
Dr Charles West was the founder (1852) of the first paediatric hospital in the English-speaking world. In a career spanning four decades, he devoted a great part of his energies to describing the nervous diseases of infants and children.
Hellal, Paula, Lorch, Marjorie
core   +1 more source

Adaptation, Reliability, and Validity of the Auditory Skills Checklist (ASC) for Bengali Speaking Children with Severe to Profound Sensorineural Hearing Loss with Hearing Aids

Makara Journal of Health Research
Background: The audiologic assessment guidelines of the American Speech-Language-Hearing Association (ASHA) encouraged functional auditory skills assessment, appropriate for age.
Istiak Rahman, Mahedi Hasan
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Objectieve beoordeling van spraakproblemen bij sprekers met dysartrie [PDF]

, 2015
Research and treatment of neurogenic speech disorders benefit from the use of reliable measurements and treatment methods. In recent years, new techniques and methods are developed that can support differential diagnosis, treatment, and progress ...
Van Brenk, Frits
core