Results 51 to 60 of about 1,813,605 (306)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Apraxia of speech due to the left postcentral gyrus lesion

Clinical Case Reports
Key Clinical Message Apraxia of speech (AOS) due to a postcentral infarction differs from conventional precentral AOS with respect to phonemic errors (phoneme substitution) which are more common than phonetic errors (phoneme distortion) and preserved ...
Naoko Mitani, Yasuhisa Sakurai
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Effect of Tongue-Tie Release on Speech Articulation and Intelligibility

Ear, Nose & Throat Journal
Objective The relationship between ankyloglossia and speech is controversial. The objective of this study was to determine the effect of tongue-tie release on speech articulation and intelligibility.
Jonathan Melong MD, BSc, Pharm, Michael Bezuhly MD, MSc, Paul Hong MD, MSc   +2 more
doaj   +1 more source

Noggin Nodding: Head Movement Correlates With Increased Effort in Accelerating Speech Production Tasks

Frontiers in Psychology, 2019
Movements of the head and speech articulators have been observed in tandem during an alternating word pair production task driven by an accelerating rate metronome. Word pairs contrasted either onset or coda dissimilarity with same word controls. Results
Mark Tiede, Christine Mooshammer, Christine Mooshammer, Louis Goldstein, Louis Goldstein   +4 more
doaj   +1 more source

Wavelets for intonation modeling in HMM speech synthesis [PDF]

, 2013
The pitch contour in speech contains information about different linguistic units at several distinct temporal scales. At the finest level, the microprosodic cues are purely segmental in nature, whereas in the coarser time scales, lexical tones, word ...
Suni, Antti Santeri, Alku, Paavo, Vainio, Martti, Suni, Antti, Aalto, Daniel, Raitio, Tuomo   +5 more
core  

Super-Wideband Spectral Envelope Modeling for Speech Coding

, 2019
Significant improvements in the quality of speech coders have been achieved by widening the coded frequency range from narrowband to wideband. However, existing speech coders still employ a limited band source-filter model extended by parametric coding ...
Fuchs, Guillaume, Bäckström, Tom, Guillaume Fuchs, Chamran Ashour, Ashour, Chamran, Tom Bäckström   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Prototype System for Selective Dissemination of Broadcast News in European Portuguese

EURASIP Journal on Advances in Signal Processing, 2007
This paper describes ongoing work on selective dissemination of broadcast news. Our pipeline system includes several modules: audio preprocessing, speech recognition, and topic segmentation and indexation.
J. Neto, I. Trancoso, D. Caseiro, H. Meinedo, R. Amaral   +4 more
doaj   +2 more sources

Speaker adaptation and the evaluation of speaker similarity in the EMIME speech-to-speech translation project [PDF]

, 2010
This paper provides an overview of speaker adaptation research carried out in the EMIME speech-to-speech translation (S2ST) project. We focus on how speaker adaptation transforms can be learned from speech in one language and applied to the acoustic ...
Tokuda, Keiichi, Shannon, Matt, Shiota, Sayaka, Wester, Mirjam; id_orcid, Oura, Keiichiro, Gibson, Matthew, Hirsimaki, Teemu, Yamagishi, Junichi, King, Simon; id_orcid, Karhila, Reima, Wu, Yi-Jian, Tian, Jilei, Dines, John, Byrne, William, Saheer, Lakshmi, Liang, Hui, Kurimo, Mikko, Garner, Philip N., Guan, Yong, King, Simon, Wester, Mirjam   +20 more
core   +1 more source