Results 101 to 110 of about 28,309,773 (304)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Speech biomarkers for automated depression level detection

Current Directions in Biomedical Engineering
This study investigates the contribution of speech audio and speech verbal content in the automated detection of depression levels. Recordings from the Distress Analysis Interview Corpus Wizard-of-Oz dataset and the depression severity labels of the ...
Aharonson Vered, Coopoo Verushen, Carlson Craig S., Postema Michiel   +3 more
doaj   +1 more source

A Three-Level Speech, Music, and Mixture Classifier

Journal of King Saud University: Engineering Sciences, 2004
Due to the new techniques of analysis and synthesis of speech signals, the musical signal processing has gained particular weight, and therefore, the classical sound analysis techniques are used in processing music signals. In this paper, a general three-
Abdullah I. Al-Shoshan, Atiyah Alatiyah, Khalid Al-Mashouq   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effects of Speech Level Shift Tested by a Non-Task-Oriented Dialog System on Text Chat Dialog with Users in Japanese: A Pilot Study

Applied Sciences
Recently, interaction between humans and dialog systems has become increasingly common and sophisticated. Humans establish good relationships with others using various linguistic considerations (e.g., politeness and speech level) in dialog.
Nozomu Nagai, Tomoki Miyamoto, Daisuke Katagami   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A Speech-Level-Based Segmented Model to Decode the Dynamic Auditory Attention States in the Competing Speaker Scenes. [PDF]

Front Neurosci, 2021
Wang L, Wang Y, Liu Z, Wu EX, Chen F.
europepmc   +1 more source

Dysarthric speech classification from coded telephone speech using glottal features

, 2021
This paper proposes a new dysarthric speech classification method from coded telephone speech using glottal features. The proposed method utilizes glottal features, which are efficiently estimated from coded telephone speech using a recently proposed ...
Alku, Paavo, Nonavinakere Prabhakera, Narendra   +1 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source