Results 71 to 80 of about 2,722,883 (334)

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Associations between teachers’ beliefs and their perception of hate speech in school: a study in Germany and Switzerland

Frontiers in Education
Hate speech is a global issue that is also prevalent among adolescents and requires an educational response. Teachers handle hate speech as part of their professional role.
Julia Kansok-Dusche, Alexander Wettstein, Saskia M. Fischer, Saskia M. Fischer, Sebastian Wachs, Sebastian Wachs, Ludwig Bilz   +6 more
doaj   +1 more source

Speech monitoring and phonologically-mediated eye gaze in language perception and production: A comparison using printed word eye-tracking

Frontiers in Human Neuroscience, 2013
The Perceptual Loop Theory of speech monitoring assumes that speakers routinely inspect their inner speech. In contrast, Huettig and Hartsuiker (2010) observed that listening to one’s own speech during language production drives eye-movements to ...
Hanna Summer Gauvin, Robert J Hartsuiker, Falk eHuettig, Falk eHuettig   +3 more
doaj   +1 more source

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

Influence of cross-linguistic exposure on speech perception under informational masking conditions: a cross-sectional study

The Egyptian Journal of Otolaryngology
Background Speech perception is often disrupted by competing sounds, which act as energetic or informational maskers. Although informational masking has been studied globally, its effects in multilingual settings where migration and exposure to ...
Prajwal Kumar Eranna, Jim Saroj Winston, Dhananjay Rachna, Pradeep Kumar Mahapatra   +3 more
doaj   +1 more source

High-density electrocorticography reveals sensorimotor cortex engagement in two distinct sites with different roles during audiovisual, audio, and visual speech perception

NeuroImage
Recent neuroimaging studies have shown the involvement of the speech motor system in the sensorimotor cortex (SMC) in speech perception, but knowledge on the relative contributions of visual and auditory speech information on SMC engagement and the ...
Anouck Schippers, Zachary V. Freudenburg, Mariska J. Vansteensel, Mathijs Raemaekers, Nick F. Ramsey   +4 more
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Auditory Speech Perception Tests in Relation to the Coding Strategy in Cochlear Implant

International Archives of Otorhinolaryngology, 2015
Introduction The objective of the evaluation of auditory perception of cochlear implant users is to determine how the acoustic signal is processed, leading to the recognition and understanding of sound.
Aline Cristine Bazon, Erika Barioni Mantello, Alina Sanches Gonçales, Myriam de Lima Isaac, Miguel Angelo Hyppolito, Ana Cláudia Mirândola Barbosa Reis   +5 more
doaj   +1 more source

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source