Results 131 to 140 of about 173,179 (314)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Stable eye versus mouth preference in a live speech-processing task. [PDF]

Sci Rep, 2023
Viktorsson C, Valtakari NV, Falck-Ytter T, Hooge ITC, Rudling M, Hessels RS.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Neurodevelopmental oscillatory basis of speech processing in noise. [PDF]

Dev Cogn Neurosci, 2023
Bertels J, Niesen M, Destoky F, Coolen T, Vander Ghinst M, Wens V, Rovai A, Trotta N, Baart M, Molinaro N, De Tiège X, Bourguignon M.   +11 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Neural Correlates of Audiovisual Speech Processing in Autistic and Non-Autistic Youth. [PDF]

Multisens Res, 2023
Dunham K, Zoltowski A, Feldman JI, Davis S, Rogers B, Failla MD, Wallace MT, Cascio CJ, Woynaroski TG.   +8 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Introducing MEG-MASC a high-quality magneto-encephalography dataset for evaluating natural speech processing. [PDF]

Sci Data, 2023
Gwilliams L, Flick G, Marantz A, Pylkkänen L, Poeppel D, King JR.   +5 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

An autoencoder and vision transformer based interpretability analysis on the performance differences in automated staging of second and third molars

Scientific Reports
The practical adoption of deep learning in high-stakes forensic applications, such as dental age estimation, is often limited by the ‘black box’ nature of the models. This study introduces a framework designed to enhance both performance and transparency
Barkin Buyukcakir, Jannick De Tobel, Patrick Thevissen, Dirk Vandermeulen, Peter Claes   +4 more
doaj   +1 more source