Results 21 to 30 of about 36,429 (223)
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Towards Automated Assessment of Stuttering and Stuttering Therapy [PDF]
arXiv, 2020 Stuttering is a complex speech disorder that can be identified by repetitions, prolongations of sounds, syllables or words, and blocks while speaking. Severity assessment is usually done by a speech therapist. While attempts at automated assessment were made, it is rarely used in therapy. Common methods for the assessment of stuttering severity include
arxiv
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
Stutter Diagnosis and Therapy System Based on Deep Learning [PDF]
arXiv, 2020 Stuttering, also called stammering, is a communication disorder that breaks the continuity of the speech. This program of work is an attempt to develop automatic recognition procedures to assess stuttered dysfluencies and use these assessments to filter out speech therapies for an individual.
arxiv
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Utilizing Speech Emotion Recognition and Recommender Systems for Negative Emotion Handling in Therapy Chatbots [PDF]
arXiv, 2023 Emotional well-being significantly influences mental health and overall quality of life. As therapy chatbots become increasingly prevalent, their ability to comprehend and respond empathetically to users' emotions remains limited. This paper addresses this limitation by proposing an approach to enhance therapy chatbots with auditory perception ...
arxiv
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Enhancing the Intelligibility of Cleft Lip and Palate Speech using Cycle-consistent Adversarial Networks [PDF]
arXiv, 2021 Cleft lip and palate (CLP) refer to a congenital craniofacial condition that causes various speech-related disorders. As a result of structural and functional deformities, the affected subjects' speech intelligibility is significantly degraded, limiting the accessibility and usability of speech-controlled devices. Towards addressing this problem, it is
arxiv
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source