Results 191 to 200 of about 38,025 (298)

A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex

Chemistry – A European Journal, EarlyView.
Targeting disease‐linked RNAs with small molecules is often limited by the modest impact of binding RNA structure alone. Here, we present a first‐in‐class bifunctional molecule that degrades the oncogenic lncRNA MALAT‐1 by inducing proximity between the RNA and a cleaving warhead.
Christian A. T. Brega, Benjamin A. Craig, Sigitas Mikutis, Rupert S. J. Proctor, Yuliia Vyborna, Maria Eleftheriou, Kostas Tzelepis, Mo Yang, Shaifaly Parmar, Javier Bonet‐Aleta, John S. Schneekloth Jr., Gonçalo J. L. Bernardes   +11 more
wiley   +1 more source

Enhancing FDM Rapid Prototyping for Industry 4.0 Applications Through Simulation and Optimization Techniques. [PDF]

Materials (Basel)
Ghinea M, Niculescu AC, Rosca BD.
europepmc   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Gut microbiome plasticity explains the altitudinal distribution pattern and adaptability in a small mammal species (<i>Apodemus draco</i>). [PDF]

Microbiol Spectr
Yun Y, Duan C, He X, Tang R, Lan Y, Lu M, Liu T, Fan X, Fan Z, Ran J.   +9 more
europepmc   +1 more source

Dynamics of bubble absorption over porous membranes in an immersed medium

Droplet, EarlyView.
The dynamics of a bubble interacting with a flat, porous superhydrophobic membrane underwater has been illustrated. Abstract Porous superhydrophobic (SHP) membranes are gaining considerable attention due to their excellent underwater absorption and drag reduction properties. They exploit the Cassie‒Baxter state of wetting to remove the bubble in a fast
Kiran Raj M
wiley   +1 more source

Resolving the boron anomaly in SrF₂-borate glasses using combined MRN-TCT-percolation framework. [PDF]

Sci Rep
El-Raouf EA, Hamalawy A, Hassan S.
europepmc   +1 more source

Effect of confining pressure on fracture characteristics and mineralogical behavior of tight sandstone specimens after hydraulic fracturing

Deep Underground Science and Engineering, EarlyView.
Hydraulic fracturing in tight sandstone and fracture propagation characteristics using backscattered electron‐scanning electron microscope (BSE‐SEM) images. Abstract This study focuses on hydraulic fracturing experiments conducted under triaxial conditions on tight sandstone specimens from Shivpuri district, Madhya Pradesh, India.
Pankaj Rawat, Narendra Kumar Samadhiya
wiley   +1 more source

Lubrication by plant-based emulsions: Linking oil-water protein-stabilized interfacial mechanical properties to oil droplet lubrication properties. [PDF]

Curr Res Food Sci
Ji L, Sagis LMC, Scholten E, Yang J.
europepmc   +1 more source

A comprehensive embryonic staging series of the turtle Trachemys scripta

Developmental Dynamics, EarlyView.
Abstract Background Turtles hold a unique place in vertebrate evolutionary history, making them critical assets in embryology research. Yet, they remain understudied as potential model organisms in the field. Here, to support experimental manipulations with turtle embryos, we have created a complete normal table of development for comprehensive ...
Christina M. Noravian, Perla G. Rand, Amira Mahomed, Annie Rickard, Oscar D. Juvera, Maria Elena de Bellard, Max Ezin   +6 more
wiley   +1 more source

Clinical features of pulmonary infarction in older patients with pulmonary embolism: a retrospective comparative study. [PDF]

Front Med (Lausanne)
Xing ZC, Yuan Y, Zhang HX, Wang JX, Zhang S.   +4 more
europepmc   +1 more source