Results 81 to 90 of about 3,284 (259)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Stability and Control of Car Dynamics with a Quarter Model via a Novel Simple Harmonic Hump under External Force

Mathematics
Effects of the road, such as speed bumps, can significantly affect a car’s stability. This study focuses on how a quarter-car model is affected by a basic harmonic speed hump and how Cubic Negative Velocity Control (CNVC) is used to control the amplitude
Khalid Alluhydan, Yasser A. Amer, Ashraf Taha EL-Sayed, Mai M. Agwa   +3 more
doaj   +1 more source

Vacuum–Laser Fabrication of Programmable Soft Actuators

Advanced Science, EarlyView.
A rapid and accessible fabrication strategy for inflatable soft actuators is presented, combining vacuum sealing with laser cutting of low‐cost thermoplastic pouches. The method enables precise sealing, fast fabrication, and programmable multi‐cell geometries.
Ashkan Rezanejad, Mostafa Mousa, Yuxuan Wang, Michael Adlerstein, Junke Yao, Antonio E. Forte   +5 more
wiley   +1 more source

Extreme Kinetic Stability and RNase Resistance of Human Telomerase RNA G‐Quadruplexes Overcome by DHX36 Helicase

Advanced Science, EarlyView.
The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo, Yashuo Zhang, Yingxian Qian, Huiying Zhan, Wenqiang Wu, Huijuan You   +5 more
wiley   +1 more source

Data‐Driven Design and Fabrication of Heat‐Resistant, Ultrastrong, Lightweight Aluminum‐Based Entropy Alloy by Additive Manufacturing

Advanced Science, EarlyView.
A data‐driven strategy integrating quantum machine learning (QML) and high‐throughput computing overcomes hot‐cracking limitation to design a novel lightweight aluminum‐based entropy alloy for additive manufacturing. The fabrication transforms brittle intermetallics into deformable hierarchical nanostructures, yielding ultrastrong strength (>1 GPa) and
Enmao Wang, Chao Ding, Danyang Zhou, Chenjin Xu, Swee Leong Sing, Jianzhong Jiang, Huibin Wu   +6 more
wiley   +1 more source

An inelastic quadrupedal model discovers four-beat walking, two-beat running, and pseudo-elastic actuation as energetically optimal.

PLoS Computational Biology, 2019
It is widely held that quadrupeds choose steady gaits that minimize their energetic cost of transport, but it is difficult to explore the entire range of possible footfall sequences empirically.
Delyle T Polet, John E A Bertram
doaj   +1 more source

Vibration levels exposed at speed bump and speed hump transitions

, 2022
The method used to eliminate the adverse effects of excessive vehicle speed in traffic operation is speed management. In the study, speed control undulations (SCUs), as one of the crucial tools of speed management in urban areas, have been evaluated in terms of their discomfort to the drivers and passengers in the passes over.
openaire   +1 more source

Engineered Strain in 2D Materials by Direct Growth on Deterministically Patterned Grayscale Topographies

Advanced Science, EarlyView.
ABSTRACT Strain is a proven technique for modifying the bandgap and enhancing carrier mobility in 2D materials. Most current strain engineering techniques rely on the post‐growth transfer of these atomically thin materials from growth substrates to target surfaces, limiting their integration into nanoelectronics.
Berke Erbas, Arindam Bala, Hernan Furci, Anushree Dutta, Naresh Kumar, Renato Zenobi, Giovanni Boero, Andras Kis, Juergen Brugger   +8 more
wiley   +1 more source

Review: Insight on Porous Carbon Positive Electrode for Sodium‐Ion Capacitors: Interplay Between Synthesis, Properties, and Performance

Advanced Science, EarlyView.
Sodium ion capacitor (SIC) is currently constrained by the low discharge capacity of commercial activated carbon as positive electrode material. This review provides a holistic summary of research efforts on alternative porous carbon materials for SIC. Image created by the authors with www.biorender.com.
Ademola Adeniji, Adrian Beda, Camélia Matei Ghimbeu   +2 more
wiley   +1 more source

Simulation of L-4 lumbar spine model of motorist exposed to vibration from speed hump. [PDF]

J Orthop, 2020
Jain A R Tony B, Alphin MS, Sri Krishnan G.   +2 more
europepmc   +1 more source