From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Application Analysis of Small Braking Control for Subway Train Special Line
In view of the special track conditions, the application of the small braking control strategy was expounded from adhesive demand, control mode, the signal source, the speed limit value and logic circuit.
HE Yuqin, ZHANGYong, ZHANG Qian
doaj
Evaluating the citywide Edinburgh 20mph speed limit intervention effects on traffic speed and volume: A pre-post observational evaluation. [PDF]
Nightingale GF +13 more
europepmc +1 more source
5+1.5 pages, 1 table, 1 figure.
Xuhui Xiao, Hai Wang, Xingze Qiu
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
THE OPERATING COSTS REDUCTION IN CASE OF THE WARNINGS ABOLISHMENT OF THE TRAINS SPEED LIMIT
The results of research of efficiency of elimination of train speed limitations are presented.
O. S. Chernyshova
doaj
Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts. [PDF]
Mines RC, Lipniacki T, Shen X.
europepmc +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Investigating the impact of a 20 miles per hour speed limit intervention on road traffic collisions, casualties, speed and volume in Belfast, UK: 3 year follow-up outcomes of a natural experiment. [PDF]
Hunter RF +10 more
europepmc +1 more source

