Results 61 to 70 of about 361,006 (254)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Speed Limits: Getting the Limit Right – the First Step in Effective Speed Management
Journal of Road Safety, 2017 The safety benefits of reducing speed limits and managing travelling speeds is well proven. However, practitioners involved in reviewing and setting speed limits continue to include practices that are based on assumptions. This paper uses a case study to
Michael de Roos, Fabian Marsh
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Transforming martensite in NiTi within nanoseconds
JPhys MaterialsMartensitic transformations enable various emerging applications like the shape memory effect and elastocaloric applications in NiTi. Increasing the speed of this transformation can shorten the response time for actuation and increase the power density ...
Klara Lünser +7 more
doaj +1 more source
Noise limited computational speed [PDF]
Applied Physics Letters, 2007 In modern transistor based logic gates, the impact of noise on computation has become increasingly relevant since the voltage scaling strategy aimed at decreasing the dissipated power, has increased the probability of error due to the reduced switching threshold voltages.
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
European Journal of Psychology Applied to Legal Context, 2012 It is hypothesized that in a given situation speeding behaviour is determined by three subjective speed assessments: the speed perceived as the riskiest, the speed perceived as the safest, and the speed perceived as the most pleasurable. Specifically, if
Florent Lheureux
doaj