Results 131 to 140 of about 4,999,897 (339)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Teaching high frequency words to poor readers using flashcards : its effects on novel word acquisition, skill trasfer to in-text word reading, and passage reading competencies : a thesis in partial fulfillment of the requirements for the degree of Master of Educational Psychology, Massey University, Albany, New Zealand [PDF]
, 2016 Several literacy reports published in the last decade have emphasised the large gap in the reading attainment of children in New Zealand. A common barrier that prevents poor readers to catch up to their peers is difficulty in reading fluency, which is ...
Iqbal, Butul Samera
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
ドウキヅケトリュウチョウナヨミノカンレンニツイテ 10プンタドクニオケルブンセキ [PDF]
, 2016 The present study is a practical research about 10-minute extensive reading-the participants read graded readers for their level for ten minutes. The purpose of the study is two fold.
城野 博志
core +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The Impact of Glaucomatous Visual Field Defects on Speed and Eye Movements during Reading
Siriraj Medical Journal, 2020 Objective: To investigate the link between glaucomatous visual field defects and reading performance by assessing reading speed and eye movements in reading.
Ai-Hong Chen +2 more
doaj
Spatial attention shifting and phonological processing in adults with dyslexia [PDF]
, 2015 According to Hari and Renvall’s (2001) sluggish attentional shifting (SAS) hypothesis people with dyslexia have a central deficit in attention shifting.
Abbott, I, Dunn, AK, Larkin, RF
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source