Results 141 to 150 of about 4,999,897 (339)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Reading errors made by skilled and unskilled readers: evaluating a system that generates reports for people with poor literacy [PDF]
, 2004 This study evaluates a natural language generation system that creates literacy assessment reports in order to create more readable documents. Prior research assessed comprehension and reading speed on modified documents.
Reiter, Ehud, Williams, Sandra
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Effectiveness of reading license technique on reading comprehension and speed among EFL students
Australian Journal of Applied LinguisticsIn exam-oriented English as foreign language (EFL) foundation programs, achieving a balance between high-stakes testing and skill-based learning remains a challenge.
Abduljalil Hazaea, Wagdi Bin-Hady
doaj +1 more source
Phonological awareness and reading speed deficits in reading disabled Greek-speaking children [PDF]
, 2009 Constantinidou, Maria +1 more
core +1 more source
Examining Rate Priming on Information Processing [PDF]
, 2017 The current study investigated the effect of a musical prime on reading rate, reading comprehension, and processing speed. This research also examined if there is a relation between reading speed and reading comprehension.
Coleman, Coryn
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source