Results 51 to 60 of about 2,323,356 (342)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

The effectiveness of new 3D visual effect speed hump in speed reduction

open access: yesMATEC Web of Conferences, 2018
Intersection is a function of parsing and altering traffic movement. The safety of vehicle manoeuvres at the junction depends on the minimum speed. The purpose of this study is to identify the effectiveness of the usage of temporary speed hump (3D visual
Ambak Kamarudin   +4 more
doaj   +1 more source

High Speed Level Converters With Short Circuit Current Reduction

open access: yesInternational Journal of Advances in Telecommunications, Electrotechnics, Signals and Systems, 2014
The level converter is used as interface between low voltages to high voltage boundary. The efficient level converter has less power consumption and less delay are the design considerations of the level shifter.
Avireni Srinivasulu   +1 more
doaj   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior   +7 more
wiley   +1 more source

High-voltage (270 V) dc power-generating system for fighter aircraft [PDF]

open access: yes, 1983
The advantages of using high voltage, direct current advanced power generating systems in fighter aircraft are discussed. Weight reduction is achieved. Efficiency is increased 85 to 90 percent by eliminating the constant speed drive.
Mcginley, K. M.
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel   +3 more
wiley   +1 more source

INFLUENCE OF OPERABILITY CRITERIA LIMITING VALUES ON SHIP SPEED

open access: yesBrodogradnja, 2016
When the ship is caught in heavy seas, there are two manoeuvres that the shipmaster can undertake to avoid excessive ship motion and hull damage: changing course or voluntary speed reduction.
Jasna Prpić-Oršić   +2 more
doaj   +1 more source

Simulating the Impact of Traffic Calming Strategies [PDF]

open access: yes, 2019
This study assessed the impact of traffic calming measures to the speed, travel times and capacity of residential roadways. The study focused on two types of speed tables, speed humps and a raised crosswalk.
Chimba, Deo, Mbuya, Christian
core   +1 more source

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